【medical-news】小剂量阿司匹林有助于降低健康女性新发哮喘几率
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NEW YORK (Reuters Health) Jun 13 - Low-dose aspirin reduced the incidence of adult-onset asthma in a large clinical trial in healthy women, investigators at Harvard Medical School report in the June issue of Thorax.
Two recently reported studies among adult men and women have indicated a significant reduction in the risk of newly diagnosed asthma associated with regular aspirin use, lead author Dr. T. Kurth and colleagues note.
To further investigate, the Boston-based researchers conducted a post hoc analysis of data from the Women's Health Study, in which female health professionals age 45 and older with no previous history of asthma were randomly assigned aspirin 100 mg every other day (n = 18,652) or placebo (n = 18,618).
During the next 10 years, there were 872 new cases of asthma diagnosed in the aspirin group and 963 in the placebo group (hazard ratio 0.90, p = 0.027).
"The magnitude of the reduction was similar across subgroups of age, smoking status, exercise, postmenopausal hormone intake and randomized vitamin E intake but was absent in those who were obese," Dr. Kurth's team reports. They note that a similar lack of benefit from aspirin among obese women was observed for the risk of ischemic stroke.
In an editorial published with the study, Dr. Andrew A. Clayton and colleagues at the Centre for Respiratory Research in Nottingham, UK, point out that women in the aspirin group had a significantly increased risk of gastrointestinal bleeding requiring blood transfusion.
"It is debatable," they say, "whether such a risk is acceptable in order to achieve the reduction in asthma risk."
They agree with the Harvard team's conclusion that "before public recommendations are provided, results from randomized trials are needed that are specifically designed to test whether low-dose aspirin reduces the risk of asthma."
Thorax 2008;63:485-486,514-518.
Two recently reported studies among adult men and women have indicated a significant reduction in the risk of newly diagnosed asthma associated with regular aspirin use, lead author Dr. T. Kurth and colleagues note.
To further investigate, the Boston-based researchers conducted a post hoc analysis of data from the Women's Health Study, in which female health professionals age 45 and older with no previous history of asthma were randomly assigned aspirin 100 mg every other day (n = 18,652) or placebo (n = 18,618).
During the next 10 years, there were 872 new cases of asthma diagnosed in the aspirin group and 963 in the placebo group (hazard ratio 0.90, p = 0.027).
"The magnitude of the reduction was similar across subgroups of age, smoking status, exercise, postmenopausal hormone intake and randomized vitamin E intake but was absent in those who were obese," Dr. Kurth's team reports. They note that a similar lack of benefit from aspirin among obese women was observed for the risk of ischemic stroke.
In an editorial published with the study, Dr. Andrew A. Clayton and colleagues at the Centre for Respiratory Research in Nottingham, UK, point out that women in the aspirin group had a significantly increased risk of gastrointestinal bleeding requiring blood transfusion.
"It is debatable," they say, "whether such a risk is acceptable in order to achieve the reduction in asthma risk."
They agree with the Harvard team's conclusion that "before public recommendations are provided, results from randomized trials are needed that are specifically designed to test whether low-dose aspirin reduces the risk of asthma."
Thorax 2008;63:485-486,514-518.
