【摘要翻译】应用小剂量环孢素A治疗间质性膀胱炎的长期疗效

文题：LONG-TERM OUTCOME OF PATIENTS WITH INTERSTITIAL CYSTITIS TREATED WITH LOW DOSE CYCLOSPORINE A.
应用小剂量环孢素A治疗间质性膀胱炎的长期疗效
作者：SAIRANEN, JUKKA; FORSELL, TAPIO; RUUTU, MIRJA
杂志全名： Journal of Urology
年份，卷（期）: 起止页码：171(6, Part 1 of 2):2138-2141, June 2004
PMID：
英文摘要：
Purpose: We evaluated patients with interstitial cystitis who had been on cyclosporine A treatment for at least a year. Symptom improvement on micturition charts and subjective expression of bladder pain were recorded. Side effects and safety of medication were evaluated.
Materials and Methods: A total of 23 patients (20 females and 3 males) fulfilling National Institute for Diabetes and Digestive and Kidney Diseases criteria of interstitial cystitis were included in this study. Age of patients at followup was 65.7 7.6 years (mean SD). Mean followup was 60.8 35.7 months. Before starting cyclosporine A treatment multiple first line therapies had been tried without clinical help.
Results: The number of voidings in 24 hours was 20.8 6.3 before treatment. After a year of cyclosporine A treatment it was decreased to 10.2 3.8 (p < 0.001). Maximal bladder capacity increased from 161.8 74.6 to 360.7 99.3 ml in a year (p < 0.001). Mean voided volume increased from 101.4 42.7 to 246.4 97.9 ml (p < 0.001). The effect was maintained throughout followup. Of 23 total patients 20 reported no bladder pain on cyclosporine A treatment and 11 patients stopped treatment due to a good clinical effect. In 9 patients symptoms recurred within months but disappeared again after cyclosporine A treatment was restarted. Side effects of medication were infrequent.
Conclusions: Cyclosporine A treatment was safe and effective in treating interstitial cystitis. The achieved therapeutic effect was maintained in the long term. Cessation of medication led to recurrence of symptoms in most cases.

中文译文：评价应用环孢素A治疗至少1年的间质性膀胱炎患者。记录排尿日记和主观的膀胱痛的症状改善情况，同时评估副作用和药物的安全性。
材料与方法：23名患者（男性3名，女性20名）均符合国家糖尿病消化和肾脏疾病研究所的间质性膀胱炎的标准，随访时年龄65.7±7.6岁。随访60.8±35.7月。患者应用环孢素A前均试验多种治疗临床无效。
结果：治疗前24小时排尿次数是20.8±6.3次。应用环孢素A治疗1年后减少为10.2±3.8次（p<0.001）。最大膀胱容量由161.8±74.6ml增加为360.7±99.3ml（p<0.001）。平均单次排尿量由101.4±42.7ml增加为246.4±97.9ml（p<0.001）。随访期间疗效始终维持。23名患者中，20名应用环孢素A治疗者报告无膀胱痛，并且11名患者因疗效满意而停止了治疗，9名患者在停药后几个月内出现了症状复发，重新开始应用环孢素A后症状又消失。药物的副作用不常见。
结论：环孢素A治疗间质性膀胱炎安全而有效。疗效可以长期维持。大多数患者停药后可以出现症状复发。

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个人评论：环孢素治疗间质性膀胱炎以前没有听说过，不过既然有说法间质性膀胱炎是自身免疫性疾病，那么用环孢素治疗就不足为怪了，随便检索了一下，发现文章却不多，3篇，一篇个案，一篇综述，另一篇见下贴，例数也不多，（检索式："Cystitis, Interstitial"[MeSH] AND "Cyclosporine"[MeSH]）有兴趣的战友可以关注一下。
另外，这篇文章例数少倒罢了，没有对照实在让人不太能理解。