【资源】Behavioral Phenotyping of Transgenic and Knockout Mice
发布于 2008-01-26 · 浏览 1510 · IP 上海上海
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What’s Wrong With My Mouse?
Behavioral Phenotyping of Transgenic and Knockout Mice
Second Edition
Jacqueline N. Crawley, Ph.D.
WILEY-INTERSCIENCE
A John Wiley & Sons, Inc., Publication
Copyright 2007 by John Wiley & Sons, Inc. All rights reserved
Published by John Wiley & Sons, Inc., Hoboken, New Jersey
Published simultaneously in Canada.
Preface ix
Preface to the First Edition xi
Acknowledgments xiii
Chapter 1 Designer Mice 1
Scope and sourcebooks
Chapter 2 Of Unicorns and Chimeras 10
How to generate a line of transgenic or knockout mouse for behavioral
phenotyping
Chapter 3 General Health 42
Give your mouse a physical
Chapter 4 Motor Functions 62
Open field, holeboard, rotarod, balance, grip, circadian activity, circling,
stereotypy, ataxic gait, seizures
Chapter 5 Sensory Abilities 86
Olfaction, vision, hearing, taste, touch, nociception
Chapter 6 Learning and Memory 110
Morris swim task, spatial mazes, cued and contextual conditioning,
conditioned taste aversion, conditioned eyeblink, olfactory discrimination,
social recognition, passive avoidance, schedule controlled operant tasks,
motor learning, attention
Chapter 7 Feeding and Drinking 164
Daily consumption, restricted access, choice tests, microstructural analysis
Chapter 8 Reproductive Behaviors 186
Sexual and parental behaviors
Chapter 9 Social Behaviors 206
Social interaction, nesting, grooming, juvenile play, aggression
Chapter 10 Emotional Behaviors: Animal Models of Psychiatric Diseases 226
Mouse models of fear, anxiety, depression, schizophrenia
Chapter 11 Reward 266
Self-administration of addictive drugs, conditioned place preference
Chapter 12 Neurodevelopment and Neurodegeneration 290
Assaying behaviors in infant, juvenile, and aged mice
Chapter 13 Putting It All Together 322
Choice of tests, order of testing, number of mice, equipment, housing and
testing environment
Chapter 14 The Next Generation 344
Conditional and inducible mutations, viral vector gene delivery, RNA
silencing, quantitative trait loci analysis, DNA microarrays, chemical
mutagenesis, gene therapy, ethical issues
References 383
Index 503
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What’s Wrong With My Mouse?
Behavioral Phenotyping of Transgenic and Knockout Mice
Second Edition
Jacqueline N. Crawley, Ph.D.
WILEY-INTERSCIENCE
A John Wiley & Sons, Inc., Publication
Copyright 2007 by John Wiley & Sons, Inc. All rights reserved
Published by John Wiley & Sons, Inc., Hoboken, New Jersey
Published simultaneously in Canada.
Preface ix
Preface to the First Edition xi
Acknowledgments xiii
Chapter 1 Designer Mice 1
Scope and sourcebooks
Chapter 2 Of Unicorns and Chimeras 10
How to generate a line of transgenic or knockout mouse for behavioral
phenotyping
Chapter 3 General Health 42
Give your mouse a physical
Chapter 4 Motor Functions 62
Open field, holeboard, rotarod, balance, grip, circadian activity, circling,
stereotypy, ataxic gait, seizures
Chapter 5 Sensory Abilities 86
Olfaction, vision, hearing, taste, touch, nociception
Chapter 6 Learning and Memory 110
Morris swim task, spatial mazes, cued and contextual conditioning,
conditioned taste aversion, conditioned eyeblink, olfactory discrimination,
social recognition, passive avoidance, schedule controlled operant tasks,
motor learning, attention
Chapter 7 Feeding and Drinking 164
Daily consumption, restricted access, choice tests, microstructural analysis
Chapter 8 Reproductive Behaviors 186
Sexual and parental behaviors
Chapter 9 Social Behaviors 206
Social interaction, nesting, grooming, juvenile play, aggression
Chapter 10 Emotional Behaviors: Animal Models of Psychiatric Diseases 226
Mouse models of fear, anxiety, depression, schizophrenia
Chapter 11 Reward 266
Self-administration of addictive drugs, conditioned place preference
Chapter 12 Neurodevelopment and Neurodegeneration 290
Assaying behaviors in infant, juvenile, and aged mice
Chapter 13 Putting It All Together 322
Choice of tests, order of testing, number of mice, equipment, housing and
testing environment
Chapter 14 The Next Generation 344
Conditional and inducible mutations, viral vector gene delivery, RNA
silencing, quantitative trait loci analysis, DNA microarrays, chemical
mutagenesis, gene therapy, ethical issues
References 383
Index 503
各位战友注意！！！！！！！！！！！
【注意】关于通过Email在论坛索取资料的管理
为了保持丁香园作为学术论坛的氛围和版面整洁，作出下列管理规定：
1、对提供资料者，我们表示感谢，希望您遵守以下规定：
1）认真介绍自己拥有的资源；
2）资料不涉及版权等法律问题；
3）提供资料时注明：“不接受回帖索取，感兴趣者请直接给我的Email信箱：abc@dxy.cn来信索取”
2、对于索取资料者，希望您遵守以下规定：
1）保证不将在丁香园免费获得的任何资源用于商业目的
2）不回帖子索取资料，而是通过Email向作者联系，保持学术论坛的氛围。
此规定自即日起开始施行，请大家努力遵守，不要违反。
对于违反者，我们将先提出警告，然后将删除帖子。
希望各专业版版主通知到本版站友，注意不要违规。
http://www.dxy.cn/bbs/post/view?bid=21&id=322656&sty=1&tpg=1&age=0
最后编辑于 2008-10-06 · 浏览 1510
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