【分享】王建枝教授关于科研选题写论文及课题申报的论文.ppt
发布于 2007-10-30 · 浏览 2.0 万 · IP 湖北湖北
这个帖子发布于 17 年零 192 天前，其中的信息可能已发生改变或有所发展。
这是同济医学院的王建枝教授在一个报告中使用的PPT，她是长***，一个特别热爱科研的学者，非常崇拜她~~
她的照片先给大家看看
申请加分！
为了表示对同济的感谢，我设置了密码，密码是：
tongji
王建枝教授简介：
王建枝，女， 1957年4月生，教授、博士生导师；长***特聘教授、国家杰出青年基金获得者、湖北省名师。华中科技大学同济医学院基础医学院副院长、病理生理学系主任；中国老年性痴呆科学家协会副主席；中国病理生理学会常务理事；湖北省暨武汉市病理生理学会理事长。从事医学基础教学和研究工作20余年。
获得的教学表彰/奖励2001年多媒体技术应用与病理生理学离体器官水平实验教学获湖北省教学成果三等奖；2004年入选国家首批“新世纪百千万人才工程”、获全国“三八红旗手”、“宝钢优秀教师奖”等；2003年“武汉市十大女杰”；2002年“获湖北省十大优秀回国人员”；2001年华中科技大学首届“十佳女教工”；2000年“湖北省高校先进女职工”；2000年华中科技大学“三育人”奖；1999年“湖北省有突出贡献的中青年专家”；2004“华中科技大学教学质量一等奖”；2004年被评为“湖北名师”。
近五年来承担的主要学术研究课题（这是两年前的资料，现在不止了）
1. 神经退行性疾病中神经细胞退行性变性机制的研究，国家自然科学基金重点项目，2005—2007，150万元，主
2. 国家自然科学基金海外青年学者合作研究基金，2004—2006，40万元，主持
3. 在神经细胞株复制阿尔茨海默病样神经原纤维退化，国家自然科学基金， 2002-2004 18万元，主持
4. 从磷酸化系统失衡研究AD发病机制、早期诊断和防治策略，国家教育部重大项目基金，2001-2004 70万元，主持
5. AD患者tau 的糖基化的研究，美国Lee基金会 2001-2006 22万美元，主持
6. AD发病机制及防治策略的研究，国家杰出青年科学基金 2000-2003 80万元，主持
7. AD发病机制、诊断及防治策略的研究，国家科技部973基金 1999-2003 77 万元，主持
近三年发表的部分代表性学术论文：
1. Li Sun, XiaoChuang Wang, Liu Shengyuan, Qun Wang, Grundke-Iqbal Inge, Iqbal Khalid and Jian-Zhi Wang. Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. FEBS Lett.579(1):251-258, 2005
2. Wang XC, Zhang J, Yu X, Han L, Zhou ZT, Zhang Y, Wang JZ. Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Acta Physiol Sin., 57(1):7-12. 2005
3. Xia-Chun Li, Ze-Fen Wang, Jun-Xia Zhang, Qun Wang and Jian-Zhi Wang. Effect of Melatonin on Calyculin A-Induced Tau Hyperphosphorylation. European J Pharmacol., 510: 25–30, 2005
4. Jia Yu Zhang, Shi Jie Liu, Hong Lian Li, and Jian-Zhi Wang. Microtubule-associated protein tau is a substrate of ATP/Mg2+-dependent proteasome protease system. J Neural Transm., 112(4):547-55. 2005
5. Chen YG. Specific tau phosphorylation sites in hippocampus correlate with impairment of step down inhibitory avoidance task in rats. Behavioural Brain Res. 158:277-284, 2005
6. Yong Jie Zhang, Ya Fei Xu, Xiao Qian Chen, Xiao Chuan Wang, Jian-Zhi Wang. Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule binding activity. FEBS Lett. In press 2005
7. Xu Li*, Fen Lu*, Qing Tian*, Ying Yang, Qun Wang and Jian-Zhi Wang. Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture. J Neural Transm. In press 2005
8. Rong Liu, Jin-Jing Pei, Xiao-Chuan Wang, Xin-Wen Zhou, Qing Tian, Bengt Winblad, Jian-Zhi Wang. Acute anoxia induces tau dephosphorylation through protein phosphatase-2A activation in rat brain slices. J Neurochem. In press 2005
9. Chen J，Li HL，Feng YM，Wang JZ. The effect of cdk-5 overexpression and overactivation on tau phosphorylation in cultured N2a cells. J Wuhan University Sc Edi, 10 (2): 472-476, 2005
10. Yan-qiu DENG, Guo-gang XU, Ping DUAN, Qi ZHANG, Jian-Zhi WANG. Effects of melatonin on wortmannin-induced tau hyperphosphorylation. Acta Pharmacologica Sinica. 26(5): 519-526, 2005
11. Hai-hong WANG, Ai-hong ZHANG, Ling-qiang ZHU, Qun WANG, Jian-zhi WANG. Overexpression of dishevelled-1 attenuates wortmannin-induced hyperphosphorylation of cytoskeletal proteins in N2a cell. Acta Pharmacologica Sinica. 26(6):679-684, 2005
12. Wang Li, Li Hong-Lian, Zhou Xin-Wen, Wang Xiao-Chuan, Zhou Ji-An and Wang Jian-zhi. Dauricine prevents bradykinin-induced alteration of calcium homeostasis and tau hyperphosphorylation in N2a cells. Acta Physiol. In press 2005
13. Shi Jie Liu, Jia Yu Zhang, Hong Lian Li, Zheng Yu Fang, Qun Wang, Heng Mei Deng, Cheng Xin Gong, Inge Grundke-Iqbal, Khalid Iqbal, and Jian-Zhi Wang. Tau Becomes a More Favorable Substrate for GSK-3 When It Is Prephosphorylated by PKA in Rat Brain. J Biol Chem. 279(48):50078-88.2004
14. Dan-Ling Wang, Zhi-Qun Ling, Fu-Yuan Cao, Ling-Qiang Zhu and Jian-Zhi Wang. Melatonin attenuates isoproterenol-induced Protein Kinase A overactivation and tau hyperphosphorylation in rat brain. J Pineal Res. 37(1):11-16，2004
15. Shupeng Li, Yanqiu Deng, YiPeng Wang and Jian-Zhi Wang. Melatonin protects SHSY5Y neuroblastoma cells from calyculin A-induces neurofilament impairment and neurotoxicity. J Pineal Res. 36(3):186-191, 2004
16. Ling Qiang Zhu, Shao Hui Wang, Zhi Qun Ling, Dan Ling Wang, and Jian-Zhi Wang. Effect of Inhibiting Melatonin Biosynthesis on Spatial Memory Retention and Tau Phosphorylation in Rat J Pineal Res. 37(2):71-77，2004
17. Tian Qing，Ling Zhiqun, Wang Jian-Zhi. Injection of okadaic acid into the Meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit. Neurosci. 126(2):277-284, 2004
18. Yafei Xu, Yongjie Zhang, and Jian-Zhi Wang. Attenuation of okadaic acid induced hyperphosphorylation of cytoskeletal proteins by heat preconditioning and its possible underlying mechanisms. Cell Stress & Chaperones. Cell Stress & Chaperones. 9(3):304-12.2004
19. WANG Xiao-Chuan, WU Yi-Gen, HU Zheng-Hui, FANG Zheng-Yu, FENG Yue,YANG Yun-Huang,WANG Qun,TANG Xiao-Wei, WANG Jian-Zhi. Correlation of Alzheimer-like tau hyperphosphorylation and fMRI BOLD intensity. J Current Alzheimer Res., 1(2): 143–145, 2004
20. Wang Yipeng, Wang Zefen, Zhang Yinchun, Yu Jin, Wang JianZhi. Endogenous production of amyloid precursor protein and amyloid b peptides inhibits serum withdrawal-induced cell differentiation. Cell Res. 14(6):467-472. 2004
21. Wang Yi-Peng, Li, Xian-Tao, Liu Shi-Jie, Zhou Xin-Wen, Wang Xiao-Chuan, Wang Jian-Zhi. Melatonin ameliorated okadaic acid induced Alzheimer-like lesions. Acta Pharmacol Sin. Acta Pharmacol Sin. 25(3):276-280. 2004
22. Liao Xiao Mei, Zhang Ying Chun，Wang Yi Peng，Wang Jian-Zhi. The effect of cdk-5 overexpression on tau hyperphosphorylation and spatial memory of rat. Science in China Ser.C Life Sciences 47(3):251-257, 2004
23. ZHANG Ying-Chun, WANG Ze-Fen, WANG Qun, WANG Yi-Peng, WANG Jian-Zhi. Melatonin attenuates overproduction of b-amyloid-induced inhibition in expression of neurofilament protein. Acta Pharmacol Sin. 25（4）：447-451, 2004
24. WANG Zefen and WANG Jian-Zhi. Overexpression of amyloid precursor protein inhibits neurite outgrowth and disrupts cytoskeleton in N2a cell. Chinese Medical J., 117（5）：775-778, 2004
25. Ling Zhiqun, Liao Xiao-Mei, Wang Jian-Zhi. Protection of melatonin on isoproterenol-induced hyperphosphorylation of tau. J Huazhong Uni. of Sci. & Tech (Nature Science Edition), 32(2): 86-88, 2004
26. Jing Yu, YanQiu Deng, Ying Yang, Jiayu Zhang, YePing Zhang, ShaoHua Zhang, Jian-Zhi Wang. Activation of glycogen synthase kinase 3 induces Alzheimer-like hyperphosphorylation of cytoskeleton protein and cell damage. Prog Biochem Biophys. 31(6)：532-537, 2004
27. Ling Zhi-Qun, Wang Xiao-Chuan, Zhang Shao-Hua, Zhang Ye-Ping and Wang Jian-Zhi. Protection of melatonin on isoproterenol-induced hyperphosphorylation of tau and spatial memory deficient in rats. Chinese J Pathophys., 20(1):6-11, 2004
28. Zheng-Hui HU, Xiao-Chuan WANG, Li-Yun LI, Mai-Li LIU, Rong LIU, Zhiqun LING, Qing TIAN, Xiao-Wei Tang, Yi-Gen WU, Jian-Zhi WANG Correlation of Behavior Changes and BOLD Signal in an Alzheimer-like Rat Model. Acta Biochem Biophysica Sinica. 36(12): 803-810 2004
29. Shi Jie Liu, Ai Hong Zhang, Hong Lian Li, Qun Wang, Heng Mei Deng, William J. Netzer, Huaxi Xu and Jian Zhi Wang. Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. J Neurochem. 87:1333-1344, 2003
30. Li Sun, Shengyuan Liu, Xin-Wen Zhou，Xiao-Chuan Wang，Rong Liu，Qun Wang， JianZhi Wang (通讯作者). Inhibition of PP2A and PP1 Induced Tau Hyperphosphorylation and Impairment of Spatial Memory Retention in Rats.Neurosci.118:1175-1182, 2003
31. Shi Jie Liu, Zheng Yu Fang, Ying Yang, Heng Mei Deng, Jian Zhi Wang. Alzheimer-like phosphorylation of tau and neurofilament induced by cocaine in vivo. Acta Pharmacol Sin. 24(6): 512-518, 2003
32. Wang Yipeng, Xinwei Zhou, XiaoChuang Wang, Rong Liu, Qun Wang, and Wang JianZhi. Detection of mRNA level and mutation of neurofilament in Alzheimer disease. Brain Aging. 3(2): 15-18, 2003
33. FANG Zheng-Yu, LIU Shi-Jie, WANG Xiao-Chuan, LIU Rong, WANG Qun, CHEN Zheng-Yue, WANG Jian-Zhi. Effect of Calpain on the Degradation of Tau in Rat Brain Cortex Extracts. Prog. Biochem.Biophys. 30(6):884-888, 2003
34. Gong CX, Wang JZ, Iqbal K, Grundke-Iqbal I. Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices. Neurosci Lett. 340(2):107-110, 2003
35. Iqbal K, Alonso Adel C, El-Akkad E, Gong CX, Haque N, Khatoon S, Pei JJ, Tanimukai H, Tsujio I, Wang JZ, Grundke-Iqba I.. Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays. J Mol Neurosci.. 20(3):425-429, 2003
36. Liu SJ and Wang JZ. Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melation, Acta Pharmacol Sin, 23(2):183-187，2002
37. Hu YY, SS He, XC Wang, QH Duan, I Grundke-Iqbal, K Iqbal and Wang JZ. Level of nonphosphorylated tau in CSF of Alzhemer disease: An Ultrasensitive bienzyme-substrate-recycle ELISA. Am J Pathol. 160(4): 1269-1278, 2002
38. Yuan-Yuan Hu, Shan-Shu He, Xiao-Chuan Wang, Qiu-Hong Duan, Sabiha Khatoon. Jian-Zhi Wang. Elevated level of phosphorylated neurofilament in CSF of AD. Neurosci Lett. 320 (3): 151-155，2002
39. Jian-Zhi Wang, Xiao-Chuan Wang, Rong-Liu, Qun-Wang, Inge Grundke-Iqbal In vitro analysis of tau phosphorylation sites and its biological activity. Chinese Medical Science Journal. 17(1):13-16, 2002
40. Tian Q and Wang Jian-Zhi (invited reviewer). Role of protein phosphatases on Alzheimer disease. Neurosignals;11:262–269，2002
41. Wang QB and Wang JZ. Injection of bradykinin or cyclosporine A to hippocampus induces Alzheimer-like phosphorylation of tau and abnormal behavior in rats. Chinese Medical Journal. 115 (6): 884-887, 2002
42. 已申报国家专利2项，国际专利1项， 均为第1完成人
获得的学术研究表彰/奖励
1． “细胞骨架蛋白异常在老年性痴呆症发病中的作用及其临床意义” 教育部提名国家科学技术奖自然科学奖一等奖，2004年 第1完成人
2． “老年性痴呆骨架蛋白异常修饰机制的研究”获中华医学一等奖，2002年 第1完成人
3． “老年性痴呆症神经原纤维变性机制的基础研究”获湖北省自然科学二等奖，2000年 第1完成人
她的照片先给大家看看
申请加分！
为了表示对同济的感谢，我设置了密码，密码是：
tongji
王建枝教授简介：
王建枝，女， 1957年4月生，教授、博士生导师；长***特聘教授、国家杰出青年基金获得者、湖北省名师。华中科技大学同济医学院基础医学院副院长、病理生理学系主任；中国老年性痴呆科学家协会副主席；中国病理生理学会常务理事；湖北省暨武汉市病理生理学会理事长。从事医学基础教学和研究工作20余年。
获得的教学表彰/奖励2001年多媒体技术应用与病理生理学离体器官水平实验教学获湖北省教学成果三等奖；2004年入选国家首批“新世纪百千万人才工程”、获全国“三八红旗手”、“宝钢优秀教师奖”等；2003年“武汉市十大女杰”；2002年“获湖北省十大优秀回国人员”；2001年华中科技大学首届“十佳女教工”；2000年“湖北省高校先进女职工”；2000年华中科技大学“三育人”奖；1999年“湖北省有突出贡献的中青年专家”；2004“华中科技大学教学质量一等奖”；2004年被评为“湖北名师”。
近五年来承担的主要学术研究课题（这是两年前的资料，现在不止了）
1. 神经退行性疾病中神经细胞退行性变性机制的研究，国家自然科学基金重点项目，2005—2007，150万元，主
2. 国家自然科学基金海外青年学者合作研究基金，2004—2006，40万元，主持
3. 在神经细胞株复制阿尔茨海默病样神经原纤维退化，国家自然科学基金， 2002-2004 18万元，主持
4. 从磷酸化系统失衡研究AD发病机制、早期诊断和防治策略，国家教育部重大项目基金，2001-2004 70万元，主持
5. AD患者tau 的糖基化的研究，美国Lee基金会 2001-2006 22万美元，主持
6. AD发病机制及防治策略的研究，国家杰出青年科学基金 2000-2003 80万元，主持
7. AD发病机制、诊断及防治策略的研究，国家科技部973基金 1999-2003 77 万元，主持
近三年发表的部分代表性学术论文：
1. Li Sun, XiaoChuang Wang, Liu Shengyuan, Qun Wang, Grundke-Iqbal Inge, Iqbal Khalid and Jian-Zhi Wang. Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. FEBS Lett.579(1):251-258, 2005
2. Wang XC, Zhang J, Yu X, Han L, Zhou ZT, Zhang Y, Wang JZ. Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat. Acta Physiol Sin., 57(1):7-12. 2005
3. Xia-Chun Li, Ze-Fen Wang, Jun-Xia Zhang, Qun Wang and Jian-Zhi Wang. Effect of Melatonin on Calyculin A-Induced Tau Hyperphosphorylation. European J Pharmacol., 510: 25–30, 2005
4. Jia Yu Zhang, Shi Jie Liu, Hong Lian Li, and Jian-Zhi Wang. Microtubule-associated protein tau is a substrate of ATP/Mg2+-dependent proteasome protease system. J Neural Transm., 112(4):547-55. 2005
5. Chen YG. Specific tau phosphorylation sites in hippocampus correlate with impairment of step down inhibitory avoidance task in rats. Behavioural Brain Res. 158:277-284, 2005
6. Yong Jie Zhang, Ya Fei Xu, Xiao Qian Chen, Xiao Chuan Wang, Jian-Zhi Wang. Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule binding activity. FEBS Lett. In press 2005
7. Xu Li*, Fen Lu*, Qing Tian*, Ying Yang, Qun Wang and Jian-Zhi Wang. Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture. J Neural Transm. In press 2005
8. Rong Liu, Jin-Jing Pei, Xiao-Chuan Wang, Xin-Wen Zhou, Qing Tian, Bengt Winblad, Jian-Zhi Wang. Acute anoxia induces tau dephosphorylation through protein phosphatase-2A activation in rat brain slices. J Neurochem. In press 2005
9. Chen J，Li HL，Feng YM，Wang JZ. The effect of cdk-5 overexpression and overactivation on tau phosphorylation in cultured N2a cells. J Wuhan University Sc Edi, 10 (2): 472-476, 2005
10. Yan-qiu DENG, Guo-gang XU, Ping DUAN, Qi ZHANG, Jian-Zhi WANG. Effects of melatonin on wortmannin-induced tau hyperphosphorylation. Acta Pharmacologica Sinica. 26(5): 519-526, 2005
11. Hai-hong WANG, Ai-hong ZHANG, Ling-qiang ZHU, Qun WANG, Jian-zhi WANG. Overexpression of dishevelled-1 attenuates wortmannin-induced hyperphosphorylation of cytoskeletal proteins in N2a cell. Acta Pharmacologica Sinica. 26(6):679-684, 2005
12. Wang Li, Li Hong-Lian, Zhou Xin-Wen, Wang Xiao-Chuan, Zhou Ji-An and Wang Jian-zhi. Dauricine prevents bradykinin-induced alteration of calcium homeostasis and tau hyperphosphorylation in N2a cells. Acta Physiol. In press 2005
13. Shi Jie Liu, Jia Yu Zhang, Hong Lian Li, Zheng Yu Fang, Qun Wang, Heng Mei Deng, Cheng Xin Gong, Inge Grundke-Iqbal, Khalid Iqbal, and Jian-Zhi Wang. Tau Becomes a More Favorable Substrate for GSK-3 When It Is Prephosphorylated by PKA in Rat Brain. J Biol Chem. 279(48):50078-88.2004
14. Dan-Ling Wang, Zhi-Qun Ling, Fu-Yuan Cao, Ling-Qiang Zhu and Jian-Zhi Wang. Melatonin attenuates isoproterenol-induced Protein Kinase A overactivation and tau hyperphosphorylation in rat brain. J Pineal Res. 37(1):11-16，2004
15. Shupeng Li, Yanqiu Deng, YiPeng Wang and Jian-Zhi Wang. Melatonin protects SHSY5Y neuroblastoma cells from calyculin A-induces neurofilament impairment and neurotoxicity. J Pineal Res. 36(3):186-191, 2004
16. Ling Qiang Zhu, Shao Hui Wang, Zhi Qun Ling, Dan Ling Wang, and Jian-Zhi Wang. Effect of Inhibiting Melatonin Biosynthesis on Spatial Memory Retention and Tau Phosphorylation in Rat J Pineal Res. 37(2):71-77，2004
17. Tian Qing，Ling Zhiqun, Wang Jian-Zhi. Injection of okadaic acid into the Meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit. Neurosci. 126(2):277-284, 2004
18. Yafei Xu, Yongjie Zhang, and Jian-Zhi Wang. Attenuation of okadaic acid induced hyperphosphorylation of cytoskeletal proteins by heat preconditioning and its possible underlying mechanisms. Cell Stress & Chaperones. Cell Stress & Chaperones. 9(3):304-12.2004
19. WANG Xiao-Chuan, WU Yi-Gen, HU Zheng-Hui, FANG Zheng-Yu, FENG Yue,YANG Yun-Huang,WANG Qun,TANG Xiao-Wei, WANG Jian-Zhi. Correlation of Alzheimer-like tau hyperphosphorylation and fMRI BOLD intensity. J Current Alzheimer Res., 1(2): 143–145, 2004
20. Wang Yipeng, Wang Zefen, Zhang Yinchun, Yu Jin, Wang JianZhi. Endogenous production of amyloid precursor protein and amyloid b peptides inhibits serum withdrawal-induced cell differentiation. Cell Res. 14(6):467-472. 2004
21. Wang Yi-Peng, Li, Xian-Tao, Liu Shi-Jie, Zhou Xin-Wen, Wang Xiao-Chuan, Wang Jian-Zhi. Melatonin ameliorated okadaic acid induced Alzheimer-like lesions. Acta Pharmacol Sin. Acta Pharmacol Sin. 25(3):276-280. 2004
22. Liao Xiao Mei, Zhang Ying Chun，Wang Yi Peng，Wang Jian-Zhi. The effect of cdk-5 overexpression on tau hyperphosphorylation and spatial memory of rat. Science in China Ser.C Life Sciences 47(3):251-257, 2004
23. ZHANG Ying-Chun, WANG Ze-Fen, WANG Qun, WANG Yi-Peng, WANG Jian-Zhi. Melatonin attenuates overproduction of b-amyloid-induced inhibition in expression of neurofilament protein. Acta Pharmacol Sin. 25（4）：447-451, 2004
24. WANG Zefen and WANG Jian-Zhi. Overexpression of amyloid precursor protein inhibits neurite outgrowth and disrupts cytoskeleton in N2a cell. Chinese Medical J., 117（5）：775-778, 2004
25. Ling Zhiqun, Liao Xiao-Mei, Wang Jian-Zhi. Protection of melatonin on isoproterenol-induced hyperphosphorylation of tau. J Huazhong Uni. of Sci. & Tech (Nature Science Edition), 32(2): 86-88, 2004
26. Jing Yu, YanQiu Deng, Ying Yang, Jiayu Zhang, YePing Zhang, ShaoHua Zhang, Jian-Zhi Wang. Activation of glycogen synthase kinase 3 induces Alzheimer-like hyperphosphorylation of cytoskeleton protein and cell damage. Prog Biochem Biophys. 31(6)：532-537, 2004
27. Ling Zhi-Qun, Wang Xiao-Chuan, Zhang Shao-Hua, Zhang Ye-Ping and Wang Jian-Zhi. Protection of melatonin on isoproterenol-induced hyperphosphorylation of tau and spatial memory deficient in rats. Chinese J Pathophys., 20(1):6-11, 2004
28. Zheng-Hui HU, Xiao-Chuan WANG, Li-Yun LI, Mai-Li LIU, Rong LIU, Zhiqun LING, Qing TIAN, Xiao-Wei Tang, Yi-Gen WU, Jian-Zhi WANG Correlation of Behavior Changes and BOLD Signal in an Alzheimer-like Rat Model. Acta Biochem Biophysica Sinica. 36(12): 803-810 2004
29. Shi Jie Liu, Ai Hong Zhang, Hong Lian Li, Qun Wang, Heng Mei Deng, William J. Netzer, Huaxi Xu and Jian Zhi Wang. Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. J Neurochem. 87:1333-1344, 2003
30. Li Sun, Shengyuan Liu, Xin-Wen Zhou，Xiao-Chuan Wang，Rong Liu，Qun Wang， JianZhi Wang (通讯作者). Inhibition of PP2A and PP1 Induced Tau Hyperphosphorylation and Impairment of Spatial Memory Retention in Rats.Neurosci.118:1175-1182, 2003
31. Shi Jie Liu, Zheng Yu Fang, Ying Yang, Heng Mei Deng, Jian Zhi Wang. Alzheimer-like phosphorylation of tau and neurofilament induced by cocaine in vivo. Acta Pharmacol Sin. 24(6): 512-518, 2003
32. Wang Yipeng, Xinwei Zhou, XiaoChuang Wang, Rong Liu, Qun Wang, and Wang JianZhi. Detection of mRNA level and mutation of neurofilament in Alzheimer disease. Brain Aging. 3(2): 15-18, 2003
33. FANG Zheng-Yu, LIU Shi-Jie, WANG Xiao-Chuan, LIU Rong, WANG Qun, CHEN Zheng-Yue, WANG Jian-Zhi. Effect of Calpain on the Degradation of Tau in Rat Brain Cortex Extracts. Prog. Biochem.Biophys. 30(6):884-888, 2003
34. Gong CX, Wang JZ, Iqbal K, Grundke-Iqbal I. Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices. Neurosci Lett. 340(2):107-110, 2003
35. Iqbal K, Alonso Adel C, El-Akkad E, Gong CX, Haque N, Khatoon S, Pei JJ, Tanimukai H, Tsujio I, Wang JZ, Grundke-Iqba I.. Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays. J Mol Neurosci.. 20(3):425-429, 2003
36. Liu SJ and Wang JZ. Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melation, Acta Pharmacol Sin, 23(2):183-187，2002
37. Hu YY, SS He, XC Wang, QH Duan, I Grundke-Iqbal, K Iqbal and Wang JZ. Level of nonphosphorylated tau in CSF of Alzhemer disease: An Ultrasensitive bienzyme-substrate-recycle ELISA. Am J Pathol. 160(4): 1269-1278, 2002
38. Yuan-Yuan Hu, Shan-Shu He, Xiao-Chuan Wang, Qiu-Hong Duan, Sabiha Khatoon. Jian-Zhi Wang. Elevated level of phosphorylated neurofilament in CSF of AD. Neurosci Lett. 320 (3): 151-155，2002
39. Jian-Zhi Wang, Xiao-Chuan Wang, Rong-Liu, Qun-Wang, Inge Grundke-Iqbal In vitro analysis of tau phosphorylation sites and its biological activity. Chinese Medical Science Journal. 17(1):13-16, 2002
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42. 已申报国家专利2项，国际专利1项， 均为第1完成人
获得的学术研究表彰/奖励
1． “细胞骨架蛋白异常在老年性痴呆症发病中的作用及其临床意义” 教育部提名国家科学技术奖自然科学奖一等奖，2004年 第1完成人
2． “老年性痴呆骨架蛋白异常修饰机制的研究”获中华医学一等奖，2002年 第1完成人
3． “老年性痴呆症神经原纤维变性机制的基础研究”获湖北省自然科学二等奖，2000年 第1完成人
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