【摘要翻译】结合粘蛋白(Tn-C)在浅表性和侵袭性膀胱肿瘤预后中的重要意义
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Prognostic significance of tenascin-C expression in superficial and invasive bladder cancer.
AIMS: Tenascin-C (Tn-C) is an extracellular matrix glycoprotein that is upregulated in malignant tumours. Tn-C promotes cell growth, cell migration, and angiogenesis. It has been suggested to be a prognostic factor in various types of malignant tumours, but there is little information on its significance in bladder cancer with regard to overall survival (OS) and recurrence free survival (RFS).
METHODS: Tn-C expression was studied in 106 patients with bladder cancer diagnosed between 1994 and 1997. Immunohistochemistry was performed using a monoclonal antibody against Tn-C. RFS and OS were estimated by the Kaplan-Meier method and compared by the log rank test in univariate analysis and by the Cox multistep regression method in multivariate analysis.
RESULTS: Within the mean follow up period of 126 months, patients with diffuse Tn-C staining in the tumour stroma had a significantly worse OS than those with negative staining or only moderate Tn-C expression (p = 0.025). Patients with cytoplasmic expression of Tn-C had a significantly better OS than those without (p = 0.001). Multivariate analysis, taking into consideration age, grade, stage, tumour associated carcinoma in situ, progression, and Tn-C staining in tumour stroma, showed that only expression of Tn-C in invasive tumour cells was an independent positive prognostic factor for OS (p = 0.049).
CONCLUSIONS: Tn-C may provide important prognostic information in bladder cancer depending on the expression pattern in the tumour stroma or cytoplasm of the tumour cells.
目的:结合粘蛋白C是一种细胞外基质糖蛋白,在恶性肿瘤中起正调节作用.结合粘蛋白C促进细胞生长,迁移和血管生成.人们认为此蛋白是不同种类恶性肿瘤的一种预后指标.但在膀胱肿瘤的总存活数(OS)和无局部复发存活数(RFS)的重要性却鲜有报道.
方法:在1994-1997之间诊断的106位膀胱癌患者研究Tn-C的表达.采用抗-Tn-C抗体进行免疫组化实验.RPS和OS采用Kaplan-Meier 方法来估计,并分别用单变量的时序检验法与多变量分析中用Cox多步回归分析了数据，并对比了二者的结果
结果:在平均126个月的随访后发现,在肿瘤间质中有弥散性Tn-C染色的患者其总存活数(OS)比那些在肿瘤间质无染色或仅微量表达的患者要显著减少(P=0.025).
在细胞质中有Tn-C表达的患者其总存活数(OS)比那些没有表达的患者要显著增加.多变量分析考虑到年龄,分级,分期,原位癌相关肿瘤,演进和肿瘤间质Tn-C染色,表明仅仅是在侵袭性膀胱肿瘤中Tn-C的表达,对于总存活数(OS)是一个独立的阳性预后指标.
结论:结合粘蛋白(Tn-C)可能在膀胱癌中隐藏着重要的预后信息,这依赖于Tn-C是在肿瘤细胞的间质中表达还是在肿瘤细胞的细胞质中表达
Prognostic significance of tenascin-C expression in superficial and invasive bladder cancer
AIMS: Tenascin-C (Tn-C) is an extracellular matrix glycoprotein that is upregulated in malignant tumours. Tn-C promotes cell growth, cell migration, and angiogenesis. It has been suggested to be a prognostic factor in various types of malignant tumours, but there is little information on its significance in bladder cancer with regard to overall survival (OS) and recurrence free survival (RFS).
METHODS: Tn-C expression was studied in 106 patients with bladder cancer diagnosed between 1994 and 1997. Immunohistochemistry was performed using a monoclonal antibody against Tn-C. RFS and OS were estimated by the Kaplan-Meier method and compared by the log rank test in univariate analysis and by the Cox multistep regression method in multivariate analysis.
RESULTS: Within the mean follow up period of 126 months, patients with diffuse Tn-C staining in the tumour stroma had a significantly worse OS than those with negative staining or only moderate Tn-C expression (p = 0.025). Patients with cytoplasmic expression of Tn-C had a significantly better OS than those without (p = 0.001). Multivariate analysis, taking into consideration age, grade, stage, tumour associated carcinoma in situ, progression, and Tn-C staining in tumour stroma, showed that only expression of Tn-C in invasive tumour cells was an independent positive prognostic factor for OS (p = 0.049).
CONCLUSIONS: Tn-C may provide important prognostic information in bladder cancer depending on the expression pattern in the tumour stroma or cytoplasm of the tumour cells.
目的:结合粘蛋白C是一种细胞外基质糖蛋白,在恶性肿瘤中起正调节作用.结合粘蛋白C促进细胞生长,迁移和血管生成.人们认为此蛋白是不同种类恶性肿瘤的一种预后指标.但在膀胱肿瘤的总存活数(OS)和无局部复发存活数(RFS)的重要性却鲜有报道.
方法:在1994-1997之间诊断的106位膀胱癌患者研究Tn-C的表达.采用抗-Tn-C抗体进行免疫组化实验.RPS和OS采用Kaplan-Meier 方法来估计,并分别用单变量的时序检验法与多变量分析中用Cox多步回归分析了数据，并对比了二者的结果
结果:在平均126个月的随访后发现,在肿瘤间质中有弥散性Tn-C染色的患者其总存活数(OS)比那些在肿瘤间质无染色或仅微量表达的患者要显著减少(P=0.025).
在细胞质中有Tn-C表达的患者其总存活数(OS)比那些没有表达的患者要显著增加.多变量分析考虑到年龄,分级,分期,原位癌相关肿瘤,演进和肿瘤间质Tn-C染色,表明仅仅是在侵袭性膀胱肿瘤中Tn-C的表达,对于总存活数(OS)是一个独立的阳性预后指标.
结论:结合粘蛋白(Tn-C)可能在膀胱癌中隐藏着重要的预后信息,这依赖于Tn-C是在肿瘤细胞的间质中表达还是在肿瘤细胞的细胞质中表达
Prognostic significance of tenascin-C expression in superficial and invasive bladder cancer
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