【讨论】对MCAO模型的新认识
发布于 2009-11-05 · 浏览 5201 · IP 江苏江苏
这个帖子发布于 15 年零 189 天前，其中的信息可能已发生改变或有所发展。
近期看了些文献，对MCAO模型有了新的认识，和大家分享一下，相互交流下！
1. http://www.dxy.cn/bbs/post/view?bid=22&id=12606636&sty=1
这是我08年发的一帖，讨论的是关于纹状体梗死的问题，现在看一文献，其中的一些话相信对我们有启发。
The most consistent pattern of cell death in MCAo follows a well-described progression from early infarction in the striatum to delayed infarction in the dorsolateral cortex overlying the striatum. Striatal infarction is mostly necrotic, occurs rapidly,and is resistant to most neuroprotective agents administered after the procedure. Cortical infarction is more delayed, involves a prolonged and biphasic opening of the blood brain barrier, and contains a greater degree of apoptotic cell death than in striatal infarction.In MCAo with reperfusion, the striatum remains densely ischemic, but the overlying cortex returns to control blood flow values. Thus, in MCAo striatal infarction is an ischemic core, and cortical infarction is a region of delayed, progressive neuronal death, or an ischemic penumbra.
1. http://www.dxy.cn/bbs/post/view?bid=22&id=12606636&sty=1
这是我08年发的一帖，讨论的是关于纹状体梗死的问题，现在看一文献，其中的一些话相信对我们有启发。
The most consistent pattern of cell death in MCAo follows a well-described progression from early infarction in the striatum to delayed infarction in the dorsolateral cortex overlying the striatum. Striatal infarction is mostly necrotic, occurs rapidly,and is resistant to most neuroprotective agents administered after the procedure. Cortical infarction is more delayed, involves a prolonged and biphasic opening of the blood brain barrier, and contains a greater degree of apoptotic cell death than in striatal infarction.In MCAo with reperfusion, the striatum remains densely ischemic, but the overlying cortex returns to control blood flow values. Thus, in MCAo striatal infarction is an ischemic core, and cortical infarction is a region of delayed, progressive neuronal death, or an ischemic penumbra.
最后编辑于 2022-10-09 · 浏览 5201
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