【进展】annualreviews.2009年最新
Transcatheter Valve Repair and Replacement
Susheel Kodali, Allan Schwartz
Annual Review of Medicine, Vol. 60: 1-11 (Volume publication date February 2009)
Role of Endothelin Receptor Antagonists in the Treatment of Pulmonary Arterial Hypertension
Steven H. Abman
Annual Review of Medicine, Vol. 60: 13-23 (Volume publication date February 2009)
Oral Iron Chelators
Maria Domenica Cappellini, Paolo Pattoneri
Annual Review of Medicine, Vol. 60: 25-38 (Volume publication date February 2009)
Treatment of HyThe perhomocysteinemia
Bradley A. Maron, Joseph Loscalzo
Annual Review of Medicine, Vol. 60: 39-54 (Volume publication date February 2009)
Stroke Rehabilitation: Strategies to Enhance Motor Recovery
Michael W. O'Dell, Chi-Chang David Lin, Victoria Harrison
Annual Review of Medicine, Vol. 60: 55-68 (Volume publication date February 2009)
Cardiomyopathic and Channelopathic Causes of Sudden Unexplained Death in Infants and Children
David J. Tester, Michael J. Ackerman
Annual Review of Medicine, Vol. 60: 69-84 (Volume publication date February 2009)
Bisphosphonate-Related Osteonecrosis of the Jaw: Diagnosis, Prevention, and Management
Salvatore L. Ruggiero, Bhoomi Mehrotra
Annual Review of Medicine, Vol. 60: 85-96 (Volume publication date February 2009)
IL-23 and Autoimmunity: New Insights into the Pathogenesis of Inflammatory Bowel Disease
Clara Abraham, Judy H. Cho
Annual Review of Medicine, Vol. 60: 97-110 (Volume publication date February 2009)
Necrotizing Enterocolitis
Marion C.W. Henry, R. Lawrence Moss
Annual Review of Medicine, Vol. 60: 111-124 (Volume publication date February 2009)
Cancer Screening: The Clash of Science and Intuition
Barnett S. Kramer, Jennifer Miller Croswell
Annual Review of Medicine, Vol. 60: 125-137 (Volume publication date February 2009)
Biomarkers for Prostate Cancer
Danil V. Makarov, Stacy Loeb, Robert H. Getzenberg, Alan W. Partin
Annual Review of Medicine, Vol. 60: 139-151 (Volume publication date February 2009)
Management of Breast Cancer in the Genome Era
Phuong Khanh H. Morrow, Gabriel N. Hortobagyi
Annual Review of Medicine, Vol. 60: 153-165 (Volume publication date February 2009)
MicroRNAs in Cancer
Ramiro Garzon, George A. Calin, Carlo M. Croce
Annual Review of Medicine, Vol. 60: 167-179 (Volume publication date February 2009)
Erythropoietin in Cancer Patients
John A. Glaspy
Annual Review of Medicine, Vol. 60: 181-192 (Volume publication date February 2009)
Thrombopoietin and Thrombopoietin Mimetics in the Treatment of Thrombocytopenia
David J. Kuter
Annual Review of Medicine, Vol. 60: 193-206 (Volume publication date February 2009)
Evolving Treatment of Advanced Colon Cancer
Neil H. Segal, Leonard B. Saltz
Annual Review of Medicine, Vol. 60: 207-219 (Volume publication date February 2009)
第一篇
Annual Review of Medicine
Vol. 60: 167-179 (Volume publication date February 2009)
(doi:10.1146/annurev.med.59.053006.104707)
MicroRNAs in Cancer
Ramiro Garzon,1 George A. Calin,2 and Carlo M. Croce3
1Department of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210
2Department of Experimental Therapeutics, University of Texas, MD Anderson Cancer Center, Houston, Texas 77020
3Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210; email: carlo.croce@osumc.edu
MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs are involved in the initiation and progression of cancer. In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer.