dxy logo
首页丁香园病例库全部版块
搜索
登录

【medical-news】【资讯翻译】Annals of Neurol:生育治疗或可加重多发性硬化

急诊科医师 · 最后编辑于 2022-10-09 · IP 山东山东
1616 浏览
这个帖子发布于 12 年零 282 天前,其中的信息可能已发生改变或有所发展。
认领翻译的战友请跟帖注明“认领本文翻译,48小时内未完成,请其他战友认领!
请根据自己专业背景选择认领,如使用翻译软件翻译,被发现者扣分1-2分
请根据自己的专业背景选择相应的资讯认领,经常认领而不能及时提供优质稿件者将被列入黑名单,取消认领资格,请大家注意!
新近参与本次活动的会员请查看:【公告】动态版重启资讯翻译计划:我为人人,人人为我,共同提高
寻找最近的翻译贴请查看:http://search.dxy.cn/?words=%E8%B5%84%E8%AE%AF%E7%BF%BB%E8%AF%91&bid=116&t=1&c=1&age=7&bid=116&limit=30&o=1
翻译时请参照版规 【版务】科技动态版版规及加分细则( 2014-02-21 更新)【注意编译和统计字数】
http://www.news-medical.net/news/20121008/Fertility-treatment-may-increase-MS-disease-activity.aspx
Fertility treatment may increase MS disease activity
Findings published in Annals of Neurology suggest that assisted reproduction technology (ART) treatment increases multiple sclerosis (MS) disease activity.

Sex hormones and gonadotropin-releasing hormone (GnRH) have both been found to play a role in autoimmune disorder pathogenesis. Small studies have shown that ART treatments for infertility, which involve hormone manipulation, increase the risk for exacerbation of MS and other autoimmune conditions. However, there has been little information to date on immunologic responses in patients with MS after ART.

Jorge Correale (Raul Carrea Institute for Neurological Research, Foundation Against Neurological Disease in Childhood, Buenos Aires, Argentina) and colleagues conducted a 5-year prospective study of 16 patients with MS who had been given 26 cycles of ART.

Seventy-five percent of patients had exacerbations of their MS after ART treatment, and during the 3-month period following ART, clinical relapses were noted in 58% of the ART cycles. The average numbers of relapses was 0.42 in a 3-month period before ART versus 3.28 in the 3 months after, representing a sevenfold increase.

Likewise, ART treatment was associated with a ninefold increase in radiologic activity, with patients having an average of 0.36 new or enlarging T2 lesions before treatment versus 1.99 after it, and 0.23 versus 1.27 gadolinium-enhancing lesions.

In the 3 months after treatment, immunologic parameters were significantly increased during cycles with relapses. There was a three- to eightfold increase in estrogen and progesterone levels, as well as elevated levels of T cells, cytokines, and antibodies against myelin-oligodendrocyte glycoprotein.

The complex and dynamic interactions between hormonal and immune factors that occur during ART treatment may affect the course of autoimmune diseases, which could explain the increased MS activity seen in this study, note Correale et al.

Given these data, when deciding which infertility treatment to administer to a patient with MS, "different hormonal approaches can be used, the choice of which depends on ART specialist recommendations," they say.

"However, neurologists should be aware of this risk, and discuss pros and cons of the procedure with MS patients."























4 收藏点赞

全部讨论(0)

默认最新
avatar
4
分享帖子
share-weibo分享到微博
share-weibo分享到微信
认证
返回顶部