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【drug-news】疫苗新剂型: 鼻内果冻

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Mmmm ... a nosejelly vaccine
By BJS
Created 09/25/2007 - 14:10

Researchers at Texas A&M University are participating in developing a medicine that is worth sneezing about: a treatment for influenza that forms a jelly when sprayed into the nose.

Even though trial treatments are being used to treat bird flu in humans, technically termed the H5N1 virus, the vaccine has the potential for numerous other uses, such as for the common flu shot, says Dr. Ian Tizard, professor of pathobiology in the College of Veterinary Medicine & Biomedical Sciences.

The project is funded in part by a $6 million grant from the National Institutes of Health awarded to DelSite Biotechnologies in conjunction with the Texas A&M teams. DelSite, an Irving-based company, has a facility in College Station.

Tizard says the method in which the vaccine gets delivered into the body is the key to the new treatment.

“We take Aloe vera leaves and put them through a series of complex extraction steps to produce a chemically pure powder, and then we combine the flu vaccine with it,” he explains.

“When this powder vaccine is puffed into the nose, it forms a jelly-like substance that clings to the inside of the nose and is absorbed into the body much more effectively. It stays longer and it has more time to do its work.”

Tizard says one or two puffs into the nose is all that’s needed in most cases to get good results. “This powder form is more effective than a liquid spray because the nose tends to clear liquid sprays out, while the powder turns into a sticky gel and can be a much more potent vaccine.

“Also, in this powder form, it can be stored for a long period of time, which is great news if thousands or even millions of doses should be needed in the case of an emergency.” Aloe vera plants are native to North Africa but can be found worldwide. There are more than 100 species of Aloe vera.

Tizard, who has conducted research using Aloe vera plants for many years, says the special carbohydrate in Aloe vera leaves is perfect for forming the gel-like substance needed to act as a carrier for the vaccine.

Tests using the new vaccine have been successful in animal trials, Tizard says, and tests on humans will begin next year.

“The plan was to try this first as a vaccine for bird flu in humans because there was an immediate concern there, and there still is the possibility that a widespread bird flu epidemic could break out somewhere in the world,” Tizard adds.

“But there is no reason to think this method of vaccine treatment would not work for many other diseases, too. We think it’s an exciting breakthrough that has great potential.”

http://www.scienceblog.com/cms/mmm-nosejelly-vaccine-14321.html

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2007-09-26 13:34 浏览 : 1334 回复 : 2

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• 🔥2021考博英语成绩部分学校已陆续开启查分通道，快来一键晒分>>

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试译一下，第一次，感觉满生涩的，呵呵。请大家批评指正：）
Mmmm ... a nosejelly vaccine （疫苗新剂型鼻内果冻）
By BJS
Created 09/25/2007 - 14:10

Researchers at Texas A&M University are participating in developing a medicine that is worth sneezing about: a treatment for influenza that forms a jelly when sprayed into the nose.
德州农工大学的研究者们，正参与研发一种值得关注的药物：该种用于治疗流感的喷鼻药物，当喷射入鼻时即可形成“鼻内果冻”状。
Even though trial treatments are being used to treat bird flu in humans, technically termed the H5N1 virus, the vaccine has the potential for numerous other uses, such as for the common flu shot, says Dr. Ian Tizard, professor of pathobiology in the College of Veterinary Medicine & Biomedical Sciences.
兽医与生物医学学院的病理学教授，Ian Tizard博士介绍，尽管此项试验是用于治疗人类禽流感病毒（学名H5N1病毒），该种剂型的疫苗仍具有广泛的潜在治疗用途，诸如用于普通流感爆发等。
The project is funded in part by a $6 million grant from the National Institutes of Health awarded to DelSite Biotechnologies in conjunction with the Texas A&M teams. DelSite, an Irving-based company, has a facility in College Station.
这项研究的部分资金，约600万美元，来自于国立卫生研究院奖励给德州农工大学与DelSite生物技术公司（一家位于IRVING市且在卡城设有研究机构的公司）联合成立研究组的拨款。
Tizard says the method in which the vaccine gets delivered into the body is the key to the new treatment.
Tizrd介绍，寻找使疫苗进入体内的有效途径，是此项研究的关键所在。
“We take Aloe vera leaves and put them through a series of complex extraction steps to produce a chemically pure powder, and then we combine the flu vaccine with it,” he explains.
“我们采用芦荟叶，通过一系列复杂的提取步序得到一种化学纯粉末，然后将流感病毒疫苗与之混合。”
“When this powder vaccine is puffed into the nose, it forms a jelly-like substance that clings to the inside of the nose and is absorbed into the body much more effectively. It stays longer and it has more time to do its work.”
“当这种携裹疫苗的粉末被抛射入鼻腔，即形成状似果冻状的物质并粘附于鼻腔内，可被更有效地吸入体内，因其在鼻内的滞留时间更长，发挥作用时间也相应更长。
Tizard says one or two puffs into the nose is all that’s needed in most cases to get good results. “This powder form is more effective than a liquid spray because the nose tends to clear liquid sprays out, while the powder turns into a sticky gel and can be a much more potent vaccine.
Tizard介绍大多数情况下喷鼻一至二次即可取得满意的效果。“这种粉末状的形式相较于液状喷雾更为有效，因为鼻腔容易清除液状喷雾，而粉末状疫苗剂型因可形成粘性的凝胶状而更为有效。
“Also, in this powder form, it can be stored for a long period of time, which is great news if thousands or even millions of doses should be needed in the case of an emergency.” Aloe vera plants are native to North Africa but can be found worldwide. There are more than 100 species of Aloe vera.
“同时，采用这种粉末状剂型，可以延长药物的保存时间，对突发状况下需要上千甚至上百万剂量的药物储备大有裨益。”尽管芦荟原产自北非，但如今已在世界各地广泛种植。全世界约有逾100种的芦荟植物。
Tizard, who has conducted research using Aloe vera plants for many years, says the special carbohydrate in Aloe vera leaves is perfect for forming the gel-like substance needed to act as a carrier for the vaccine.
Tizard博士作为多年以来将芦荟引入此项研究的倡导者，发现芦荟叶中的一种特殊的多糖成分，对构成凝胶状疫苗载体起着关键作用。
Tests using the new vaccine have been successful in animal trials, Tizard says, and tests on humans will begin next year.
此种新型疫苗已在动物实验中取得成功，明年将进行人体试验。
“The plan was to try this first as a vaccine for bird flu in humans because there was an immediate concern there, and there still is the possibility that a widespread bird flu epidemic could break out somewhere in the world,” Tizard adds.
由于禽流感是当今的热点所系，并且仍有可能在局部地区大规模爆发，因此此项研究开始将注意力投射于禽流感病毒疫苗。
“But there is no reason to think this method of vaccine treatment would not work for many other diseases, too. We think it’s an exciting breakthrough that has great potential.”
“但是我们相信，这项技术仍可用于许多其它疾病的防治。这个振奋人心的突破存在着广阔的前景。”

2007-09-26 23:00

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苏幕遮编辑于 2007-09-28 22:29

• 考博成绩结果不错，

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补充一下，呵呵，google来的：）
德州农工大学是德州境内第 1 所公立高等教育学府，在1876 年以德州农工学院〈The Agricultural and Mechanical College of Texas 〉为名建校。受惠于1862 年美国政府所颁行的默里法案〈Morrill Act 〉，德州农工学院由政府手上接收到了大笔的经费与土地，并且在短时间内将该校的校誉推向高峰。德州农工大学位于中德州（ Texas ）的卡城（College Station ），卡城位于中德州，是由College Station 与Bryan 两个人口稠密区联合而成的中型都市。College Station 与Bryan 的都市发展完全以德州农工大学为中心。卡城是个历史比较悠久的城市，它的总人口数为 15 万人。最接近卡城的大型都会区是休斯敦，位于卡城东南方约两小时车程。而卡城离德州首都奥斯汀也不算远；交通运输方便也促进卡城生活机能的便利。
Delsite biotechology是Carrington Laboratories公司的子公司，曾与Invitrogen公司合作，利用Invitroge公司的技术PD-DirectTM细胞培养技术开发H5N1型灭火疫苗。

另外是关于鼻内非损伤性免疫途径的
最近，以鼻腔作为非损伤性免疫途径日益得到重视。eyles等研究了破伤风类毒素的溶液和微球鼻腔给药的给药量与免疫反应的关系，指出鼻腔可作为非损伤性免疫途径。
hu等研究发现呼吸道合胞体病毒(respiratory syncytial virus,rsv)的免疫刺激复合物鼻腔给药较皮下注射能产生更快、更强、更加持久的局部和系统抗体反应。

2007-09-28 22:50

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苏幕遮编辑于 2007-09-28 23:24

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