【文摘发布】移植耐受：从啮齿类试验动物模型所知的
这个帖子发布于 17 年零 287 天前，其中的信息可能已发生改变或有所发展。
Title：Transplantation tolerance: lessons from experimental rodent models
Author：Cherry I. Kingsley, Satish N. Nadig and Kathryn J. Wood.
Source：Transplant International Volume 20 Issue 10 Page 828-841, October 2007
Abstract：Immunological tolerance or functional unresponsiveness to a transplant is arguably the only approach that is likely to provide long-term graft survival without the problems associated with life-long global immunosuppression. Over the past 50 years, rodent models have become an invaluable tool for elucidating the mechanisms of tolerance to alloantigens. Importantly, rodent models can be adapted to ensure that they reflect more accurately the immune status of human transplant recipients. More recently, the development of genetically modified mice has enabled specific insights into the cellular and molecular mechanisms that play a key role in both the induction and maintenance of tolerance to be obtained and more complex questions to be addressed. This review highlights strategies designed to induce alloantigen specific immunological unresponsiveness leading to transplantation tolerance that have been developed through the use of experimental models.
Author：Cherry I. Kingsley, Satish N. Nadig and Kathryn J. Wood.
Source：Transplant International Volume 20 Issue 10 Page 828-841, October 2007
Abstract：Immunological tolerance or functional unresponsiveness to a transplant is arguably the only approach that is likely to provide long-term graft survival without the problems associated with life-long global immunosuppression. Over the past 50 years, rodent models have become an invaluable tool for elucidating the mechanisms of tolerance to alloantigens. Importantly, rodent models can be adapted to ensure that they reflect more accurately the immune status of human transplant recipients. More recently, the development of genetically modified mice has enabled specific insights into the cellular and molecular mechanisms that play a key role in both the induction and maintenance of tolerance to be obtained and more complex questions to be addressed. This review highlights strategies designed to induce alloantigen specific immunological unresponsiveness leading to transplantation tolerance that have been developed through the use of experimental models.
2 收藏点赞
