【medical-news】颈动脉狭窄与血管事件相关
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Carotid Artery Stenosis Linked to Vascular Events
NEW YORK (Reuters Health) May 09 - Asymptomatic carotid artery stenosis (CAS) is associated with new vascular events in patients with clinical manifestations of arterial disease, Dutch researchers report in the May issue of Stroke.
Dr. Yolanda van der Graaf of UMC Utrecht and colleagues note that the prognostic value of CAS has been examined in the general population but less often in patients with apparent arterial disease other than retinal or cerebral ischemia.
To investigate further, the researchers examined data on 2684 patients with clinical manifestations of arterial disease or type 2 diabetes mellitus, but without a history of cerebral ischemia.
In all, 221 (8%) of the subjects had asymptomatic CAS of 50% or greater. During a mean follow-up of 3.6 years, a first vascular event occurred in 253 patients (9%).
The cumulative incidence rate for the composite of subsequent vascular events after 5 years was 12.3%. It was 2.2% for cerebral infarction and 8.0% for myocardial infarction.
After adjustment, those with asymptomatic CAS had a hazard ratio of 1.5 for subsequent vascular events and a hazard ratio of 1.8 for vascular death.
In addition, say the investigators, the relative risk of any recurrent vascular events increased as the extent of asymptomatic CAS increased.
In conclusion, the team observes, "asymptomatic CAS of 50% or greater is an independent predictor of vascular events, in particular of vascular death," in patients with evident arterial disease or type 2 diabetes.
Stroke 2007;38:1470-1475.
http://www.medscape.com/viewarticle/556281
NEW YORK (Reuters Health) May 09 - Asymptomatic carotid artery stenosis (CAS) is associated with new vascular events in patients with clinical manifestations of arterial disease, Dutch researchers report in the May issue of Stroke.
Dr. Yolanda van der Graaf of UMC Utrecht and colleagues note that the prognostic value of CAS has been examined in the general population but less often in patients with apparent arterial disease other than retinal or cerebral ischemia.
To investigate further, the researchers examined data on 2684 patients with clinical manifestations of arterial disease or type 2 diabetes mellitus, but without a history of cerebral ischemia.
In all, 221 (8%) of the subjects had asymptomatic CAS of 50% or greater. During a mean follow-up of 3.6 years, a first vascular event occurred in 253 patients (9%).
The cumulative incidence rate for the composite of subsequent vascular events after 5 years was 12.3%. It was 2.2% for cerebral infarction and 8.0% for myocardial infarction.
After adjustment, those with asymptomatic CAS had a hazard ratio of 1.5 for subsequent vascular events and a hazard ratio of 1.8 for vascular death.
In addition, say the investigators, the relative risk of any recurrent vascular events increased as the extent of asymptomatic CAS increased.
In conclusion, the team observes, "asymptomatic CAS of 50% or greater is an independent predictor of vascular events, in particular of vascular death," in patients with evident arterial disease or type 2 diabetes.
Stroke 2007;38:1470-1475.
http://www.medscape.com/viewarticle/556281
