【medical-news】肺炎衣原体感染与女孩哮喘有关
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Chlamydia Pneumoniae May Be Linked to Asthma in Girls
NEW YORK (Reuters Health) Dec 14 - There appears to be an association between Chlamydia pneumoniae infection and wheezing, particularly in girls, a multinational team reports.
Dr. Erik Normann of Uppsala University, Sweden, and colleagues note that there is evidence linking C. pneumoniae and wheezing in childhood, but the details are unclear.
To investigate further, the researchers studied data for 1581 children, age 4 years, who had been followed since birth. They had been tested for antibodies to C. pneumoniae and to common allergens.
In all, 159 (10.1%) had detectable levels of IgG antibodies to C. pneumoniae. There was no significant difference in incidence between boys and girls, the researcher report on the current issue of Thorax.
Although IgG antibodies to C. pneumoniae were associated with wheezing reported at various ages, the findings generally were not significant. Moreover, the association was not seen in boys.
However, at the age of 1 year, in girls, C. pneumoniae IgC was tied to an odds ratio of wheezing of 3.4. By the age of 4 years, the corresponding ratio was 2.01. In those with the highest IgC levels, the association was even more pronounced.
When further stratified by IgE sensitization to allergens, girls without sensitization were at significantly increased risk of wheezing compared to those who were IgE sensitized.
Summing up, Dr. Normann told Reuters Health that "if the result of our study turns out to be true, that there is an association between infections with C. pneumoniae and asthma, then, in a future, it is possible that a vaccine against C. pneumoniae might reduce the prevalence of asthma."
http://www.medscape.com/viewarticle/549385
NEW YORK (Reuters Health) Dec 14 - There appears to be an association between Chlamydia pneumoniae infection and wheezing, particularly in girls, a multinational team reports.
Dr. Erik Normann of Uppsala University, Sweden, and colleagues note that there is evidence linking C. pneumoniae and wheezing in childhood, but the details are unclear.
To investigate further, the researchers studied data for 1581 children, age 4 years, who had been followed since birth. They had been tested for antibodies to C. pneumoniae and to common allergens.
In all, 159 (10.1%) had detectable levels of IgG antibodies to C. pneumoniae. There was no significant difference in incidence between boys and girls, the researcher report on the current issue of Thorax.
Although IgG antibodies to C. pneumoniae were associated with wheezing reported at various ages, the findings generally were not significant. Moreover, the association was not seen in boys.
However, at the age of 1 year, in girls, C. pneumoniae IgC was tied to an odds ratio of wheezing of 3.4. By the age of 4 years, the corresponding ratio was 2.01. In those with the highest IgC levels, the association was even more pronounced.
When further stratified by IgE sensitization to allergens, girls without sensitization were at significantly increased risk of wheezing compared to those who were IgE sensitized.
Summing up, Dr. Normann told Reuters Health that "if the result of our study turns out to be true, that there is an association between infections with C. pneumoniae and asthma, then, in a future, it is possible that a vaccine against C. pneumoniae might reduce the prevalence of asthma."
http://www.medscape.com/viewarticle/549385
