【medical-news】Childhood leukemia, brain tumor survivors at risk for stroke
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Childhood leukemia, brain tumor survivors at risk for stroke
12/1/2006
By: Reuters Health
NEW YORK (Reuters Health), Dec 1 - Survivors of childhood leukemia and brain tumors are at increased risk of stroke later in life, a study shows. This is particularly true for those treated with cranial radiotherapy at doses greater than 30 Gy.
The findings justify continued efforts to reduce radiation doses among children with leukemia or brain tumors "whenever practical," conclude Dr. Daniel C. Bowers from the University of Texas Southwestern Medical School, Dallas, and colleagues, writing in the Journal of Clinical Oncology dated November 20.
Their study included 4,828 leukemia survivors and 1,871 brain tumor survivors who were younger than 21 years when diagnosed between 1970 and 1986, as well as a comparison group of 3,846 siblings of the cancer survivors.
This is the first study, the authors say, to look at the risk of late-occurring stroke among childhood leukemia survivors and is "by far the largest study" to examine the risk of stroke in childhood brain tumor survivors.
According to the team, 37 leukemia survivors and 63 brain tumor survivors experienced a late-occurring stroke (i.e., occurring five or more years after diagnosis).
Compared with the sibling comparison group, the relative risk of stroke for leukemia and brain tumor survivors was 6.4 and 29.0, respectively.
Mean cranial radiotherapy at a dose of 30 Gy or greater was associated with increased stroke risk in both leukemia and brain tumor survivors in a dose-dependent fashion.
"Importantly, although the risk of stroke among leukemia and brain tumor survivors is significantly increased, it is still a relatively uncommon event during the first two decades after the cancer diagnosis," the authors note.
The rate of late-occurring stroke for leukemia survivors was 57.9 per 100,000 person-years; it was 267.6 per 100,000 person-years for brain tumor survivors.
"How this risk will change as these cancer survivors age is not known," the study team points out.
Last Updated: 2006-12-01 11:17:53 -0400 (Reuters Health)
J Clin Oncol 2006;24:5277-5282.
http://www.auntminnie.com/index.asp?Sec=sup&Sub=roc&Pag=dis&ItemId=73847
12/1/2006
By: Reuters Health
NEW YORK (Reuters Health), Dec 1 - Survivors of childhood leukemia and brain tumors are at increased risk of stroke later in life, a study shows. This is particularly true for those treated with cranial radiotherapy at doses greater than 30 Gy.
The findings justify continued efforts to reduce radiation doses among children with leukemia or brain tumors "whenever practical," conclude Dr. Daniel C. Bowers from the University of Texas Southwestern Medical School, Dallas, and colleagues, writing in the Journal of Clinical Oncology dated November 20.
Their study included 4,828 leukemia survivors and 1,871 brain tumor survivors who were younger than 21 years when diagnosed between 1970 and 1986, as well as a comparison group of 3,846 siblings of the cancer survivors.
This is the first study, the authors say, to look at the risk of late-occurring stroke among childhood leukemia survivors and is "by far the largest study" to examine the risk of stroke in childhood brain tumor survivors.
According to the team, 37 leukemia survivors and 63 brain tumor survivors experienced a late-occurring stroke (i.e., occurring five or more years after diagnosis).
Compared with the sibling comparison group, the relative risk of stroke for leukemia and brain tumor survivors was 6.4 and 29.0, respectively.
Mean cranial radiotherapy at a dose of 30 Gy or greater was associated with increased stroke risk in both leukemia and brain tumor survivors in a dose-dependent fashion.
"Importantly, although the risk of stroke among leukemia and brain tumor survivors is significantly increased, it is still a relatively uncommon event during the first two decades after the cancer diagnosis," the authors note.
The rate of late-occurring stroke for leukemia survivors was 57.9 per 100,000 person-years; it was 267.6 per 100,000 person-years for brain tumor survivors.
"How this risk will change as these cancer survivors age is not known," the study team points out.
Last Updated: 2006-12-01 11:17:53 -0400 (Reuters Health)
J Clin Oncol 2006;24:5277-5282.
http://www.auntminnie.com/index.asp?Sec=sup&Sub=roc&Pag=dis&ItemId=73847
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