【medical-news】雌性激素可以治疗脑损伤
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Female hormone may treat brain injuries
雌性激素可以治疗脑损伤
Last Updated: 2006-10-02 17:00:42 -0400 (Reuters Health)
NEW YORK (Reuters Health) - Treatment with progesterone, a well-known hormone that prepares the womb for pregnancy, safely reduces the risk of death and disability in people who suffer a traumatic brain injury, new research suggests.
纽约（路透社）-应用黄体酮（这种激素能使子宫适于怀孕）治疗确实可以减小脑外伤病人的死亡和致残几率。。
Animal studies have indicated that giving progesterone soon after injury reduces brain swelling, prevents nerve death and improves functional outcomes. Lead researcher Dr. David W. Wright and colleagues note that progesterone's advantages over other potential treatments include its ability to quickly enter the brain, history of safe use, ease of administration, and low cost.
动物研究表明，在损伤之后马上给与黄体酮能够减少脑水肿，阻止神经死亡和改善功能性预后。首席研究者David W. Wright博士及其同事说，黄体酮优于其它疗法之处在于它能够迅速进入脑内，长时间安全使用，给药方便和廉价。
Wright, from Emory University in Atlanta, and colleagues included in their study 100 adults with brain injury who reached the emergency department within 11 hours of injury. Patients were randomly assigned to receive an intravenous dose of progesterone or inactive "placebo".
来自亚特兰大Emory 大学的Wright及其同事把100例在脑损伤后11小时内送到急救室的患者作为研究对象。患者被随机分组，静脉注射一定剂量的黄体酮或者无作用的安慰剂。
The death rate in the 30 days after injury was 13 percent in the progesterone group compared with 30 percent in the comparison group. This suggests that progesterone cut the risk of death by 57 percent.
损伤后30天的死亡率在给与黄体酮组为13%，而在对照组则高达30%。这表明黄体酮降低了57%的死亡风险。
Aside from some minor inflammation at the progesterone injection site, the side effects seen with the hormone were comparable to those observed with placebo. No serious side effects were seen in either group.
除了注射部位较小的感染之外，激素和安慰剂的副作用无区别。在两组中都没有严重的副作用。
Wright's team was able to contact 92 percent of patients who survived 30 days. There was evidence that progesterone improved the recovery of patients with moderate brain injury. Patients with severe injury seemed to glean no benefit from the hormone.
Wright的研究小组能够随访到92%的30天内存活的患者。有证据表明黄体酮能够促进中度脑损伤患者的康复，对重度损伤好像没有作用。
One-year outcomes will be reported later, the authors note. Still, the findings are encouraging and indicate the need for additional studies to investigate this topic further.
作者说，一年期研究结果将在以后报道。然而，这个发现是令人鼓舞的，它表明有必要对这个课题的进一步研究。
SOURCE: Annals of Emergency Medicine, October 2, 2006, online.
雌性激素可以治疗脑损伤
Last Updated: 2006-10-02 17:00:42 -0400 (Reuters Health)
NEW YORK (Reuters Health) - Treatment with progesterone, a well-known hormone that prepares the womb for pregnancy, safely reduces the risk of death and disability in people who suffer a traumatic brain injury, new research suggests.
纽约（路透社）-应用黄体酮（这种激素能使子宫适于怀孕）治疗确实可以减小脑外伤病人的死亡和致残几率。。
Animal studies have indicated that giving progesterone soon after injury reduces brain swelling, prevents nerve death and improves functional outcomes. Lead researcher Dr. David W. Wright and colleagues note that progesterone's advantages over other potential treatments include its ability to quickly enter the brain, history of safe use, ease of administration, and low cost.
动物研究表明，在损伤之后马上给与黄体酮能够减少脑水肿，阻止神经死亡和改善功能性预后。首席研究者David W. Wright博士及其同事说，黄体酮优于其它疗法之处在于它能够迅速进入脑内，长时间安全使用，给药方便和廉价。
Wright, from Emory University in Atlanta, and colleagues included in their study 100 adults with brain injury who reached the emergency department within 11 hours of injury. Patients were randomly assigned to receive an intravenous dose of progesterone or inactive "placebo".
来自亚特兰大Emory 大学的Wright及其同事把100例在脑损伤后11小时内送到急救室的患者作为研究对象。患者被随机分组，静脉注射一定剂量的黄体酮或者无作用的安慰剂。
The death rate in the 30 days after injury was 13 percent in the progesterone group compared with 30 percent in the comparison group. This suggests that progesterone cut the risk of death by 57 percent.
损伤后30天的死亡率在给与黄体酮组为13%，而在对照组则高达30%。这表明黄体酮降低了57%的死亡风险。
Aside from some minor inflammation at the progesterone injection site, the side effects seen with the hormone were comparable to those observed with placebo. No serious side effects were seen in either group.
除了注射部位较小的感染之外，激素和安慰剂的副作用无区别。在两组中都没有严重的副作用。
Wright's team was able to contact 92 percent of patients who survived 30 days. There was evidence that progesterone improved the recovery of patients with moderate brain injury. Patients with severe injury seemed to glean no benefit from the hormone.
Wright的研究小组能够随访到92%的30天内存活的患者。有证据表明黄体酮能够促进中度脑损伤患者的康复，对重度损伤好像没有作用。
One-year outcomes will be reported later, the authors note. Still, the findings are encouraging and indicate the need for additional studies to investigate this topic further.
作者说，一年期研究结果将在以后报道。然而，这个发现是令人鼓舞的，它表明有必要对这个课题的进一步研究。
SOURCE: Annals of Emergency Medicine, October 2, 2006, online.
