【medical-news】2型糖尿病增加结肠息肉，结肠癌的风险性
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Type 2 diabetes ups risk for colon polyps, cancer
Reuters Health
Tuesday, August 29, 2006
NEW YORK (Reuters Health) - Type 2 or non-insulin dependent diabetes is associated with increased risk of developing colorectal cancer, particularly among men, according to a study reported in the American Journal of Gastroenterology.
Many studies that have examined the connection between diabetes and colorectal cancer have yielded contradictory results, Dr. Paul J. Limburg and his research team note, and they attribute this to shortcomings in the studies.
To avoid these pitfalls, Limburg, from Mayo Clinic College of Medicine in Rochester, Minnesota, and his group evaluated data from the Rochester Epidemiology Project, which has medical information for close to 86,000 residents. They analyzed the relationship between a diagnosis of type 2 diabetes between 1970 ann 1994 and the subsequent occurrence rate of colorectal cancer through 1999.
There were 1,975 residents with diabetes and 51 cases of colorectal cancer.
After accounting for age and calendar period, the standardized incidence ratio (SIR) -- the ratio of the observed to the expected number new cases of cancer -- was 1.39, or 39% higher than expected among people with diabetes. However, the association was statistically significant only among men, for whom the SIR was 1.67.
The risk of colorectal cancer was significantly higher for diabetics who were current or former smokers, so the researchers think that men's higher propensity to smoke may have influenced the difference in risk.
"Colorectal cancer screening ... and tobacco cessation should be strongly emphasized for type 2 diabetes patients," Limburg and his associates advise.
SOURCE: American Journal of Gastroenterology, August 2006.
2型糖尿病增加结肠息肉，结肠癌的风险性
纽约（路透社健康资讯）报道——根据一项在美国胃肠病学杂志发表的研究结果，2型糖尿病或称非胰岛素依赖型糖尿病与发生结直肠癌的风险性增加相关，尤其在男人中。
许多研究检测了糖尿病与结直肠癌之间的联系并得出了互相矛盾的结果，Dr. Paul J. Limburg和他的研究小组指出，他们将这种情况归因于研究的缺陷。
为避免这些缺陷，来自于明尼苏达州罗彻斯特梅奥临床医学院的Limburg和他的小组评估了罗彻斯特流行病学计划的资料，这其中包括接近86,000居民的医学资料。他们分析了自1970年到1994年间诊断为糖尿病的患者及这些患者随后直到1999年结直肠癌的发生率间的关系。
有1975名居民患糖尿病，51例结直肠癌患者。
去除年龄和时代因素干扰后，标准化发生率——观察到的新患病例数与预期例数的比值——为1.39，或者说在糖尿病患者中结直肠癌的实际发生率比预期的高39%。然而，糖尿病与结直肠癌发病间的关系仅在男性中有统计学意义，其SIR（标准化发生率）为1.67。
在正在吸烟或曾经吸烟的糖尿病患者中结直肠癌的发生率明显增高，因此研究者认为男性的较高吸烟嗜好影响了两性中患病风险的差异。
“结直肠癌筛查和戒烟应重点强调对于2型糖尿病患者” Limburg和他的助手们建议。
不好意思，这篇文章老了点，但是看完想翻译了的，因有事一直就拖到现在，愿与大家共同学习，感觉有些地方翻译的不太确切，希望高人指点。
Reuters Health
Tuesday, August 29, 2006
NEW YORK (Reuters Health) - Type 2 or non-insulin dependent diabetes is associated with increased risk of developing colorectal cancer, particularly among men, according to a study reported in the American Journal of Gastroenterology.
Many studies that have examined the connection between diabetes and colorectal cancer have yielded contradictory results, Dr. Paul J. Limburg and his research team note, and they attribute this to shortcomings in the studies.
To avoid these pitfalls, Limburg, from Mayo Clinic College of Medicine in Rochester, Minnesota, and his group evaluated data from the Rochester Epidemiology Project, which has medical information for close to 86,000 residents. They analyzed the relationship between a diagnosis of type 2 diabetes between 1970 ann 1994 and the subsequent occurrence rate of colorectal cancer through 1999.
There were 1,975 residents with diabetes and 51 cases of colorectal cancer.
After accounting for age and calendar period, the standardized incidence ratio (SIR) -- the ratio of the observed to the expected number new cases of cancer -- was 1.39, or 39% higher than expected among people with diabetes. However, the association was statistically significant only among men, for whom the SIR was 1.67.
The risk of colorectal cancer was significantly higher for diabetics who were current or former smokers, so the researchers think that men's higher propensity to smoke may have influenced the difference in risk.
"Colorectal cancer screening ... and tobacco cessation should be strongly emphasized for type 2 diabetes patients," Limburg and his associates advise.
SOURCE: American Journal of Gastroenterology, August 2006.
2型糖尿病增加结肠息肉，结肠癌的风险性
纽约（路透社健康资讯）报道——根据一项在美国胃肠病学杂志发表的研究结果，2型糖尿病或称非胰岛素依赖型糖尿病与发生结直肠癌的风险性增加相关，尤其在男人中。
许多研究检测了糖尿病与结直肠癌之间的联系并得出了互相矛盾的结果，Dr. Paul J. Limburg和他的研究小组指出，他们将这种情况归因于研究的缺陷。
为避免这些缺陷，来自于明尼苏达州罗彻斯特梅奥临床医学院的Limburg和他的小组评估了罗彻斯特流行病学计划的资料，这其中包括接近86,000居民的医学资料。他们分析了自1970年到1994年间诊断为糖尿病的患者及这些患者随后直到1999年结直肠癌的发生率间的关系。
有1975名居民患糖尿病，51例结直肠癌患者。
去除年龄和时代因素干扰后，标准化发生率——观察到的新患病例数与预期例数的比值——为1.39，或者说在糖尿病患者中结直肠癌的实际发生率比预期的高39%。然而，糖尿病与结直肠癌发病间的关系仅在男性中有统计学意义，其SIR（标准化发生率）为1.67。
在正在吸烟或曾经吸烟的糖尿病患者中结直肠癌的发生率明显增高，因此研究者认为男性的较高吸烟嗜好影响了两性中患病风险的差异。
“结直肠癌筛查和戒烟应重点强调对于2型糖尿病患者” Limburg和他的助手们建议。
不好意思，这篇文章老了点，但是看完想翻译了的，因有事一直就拖到现在，愿与大家共同学习，感觉有些地方翻译的不太确切，希望高人指点。
