dxy logo
首页丁香园病例库全部版块
搜索
登录

Comparing genomic expression patterns across species

发布于 2004-02-03 · 浏览 573 · IP 上海上海
这个帖子发布于 21 年零 101 天前,其中的信息可能已发生改变或有所发展。
Comparing genomic expression patterns across species identifies shared transcriptional profile in aging

nature genetics:volume 36 no. 2 pp 197 - 204

We developed a method for systematically comparing gene expression patterns across organisms using genome-wide comparative analysis of DNA microarray experiments. We identified analogous gene expression programs comprising shared patterns of regulation across orthologous genes. Biological features of these patterns could be identified as highly conserved subpatterns that correspond to Gene Ontology categories. Here, we demonstrate these methods by analyzing a specific biological process, aging, and show that similar analysis can be applied to a range of biological processes. We found that two highly diverged animals, the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster, implement a shared adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport. Most of these changes were implemented early in adulthood. Using this approach to search databases of gene expression data, we found conserved transcriptional signatures in larval development, embryogenesis, gametogenesis and mRNA degradation.

http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v36/n2/abs/ng1291.html





最后编辑于 2022-10-09 · 浏览 573

5 收藏点赞

全部讨论0

默认最新
avatar
5
分享帖子
share-weibo分享到微博
share-weibo分享到微信
认证
返回顶部