Priming of naive T cells leads to eradication of tumor
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文题: Priming of naive T cells inside tumors leads to eradication of established tumors.
作者：Yu P, Lee Y, Liu W, Chin RK, Wang J, Wang Y, Schietinger A, Philip M, Schreiber
H, Fu YX.
杂志全名： Nature Immunology.
年份，卷（期）: 起止页码：2004 Jan 4 [Epub ahead of print].
The tumor barrier comprised of nonantigenic stromal cells may contribute to the failure of tumor rejection. The tumor-necrosis factor superfamily member LIGHT (also known as TNFSF-14) is a ligand of stromal cell-expressed lymphotoxin-betta receptor and T cell-expressed herpes viral entry mediator (HVEM). Here we show that forced expression of LIGHT in the tumor environment induces a massive infiltration of naive T lymphocytes that correlates with an upregulation of both chemokine production and expression of adhesion molecules. Activation of these infiltrating T cells, possibly through HVEM, leads to the rejection of established, highly progressive tumors at local and distal sites. Our study indicates that targeting the tumor barrier may be an effective strategy for cancer immunotherapy.
由非抗原性基质细胞构成的肿瘤屏障的形成可能归因于机体对肿瘤抵制的失败。肿瘤坏死因子超家族成员LIGHT（也称为TNFSF-14）是基质细胞表达的淋巴毒素- beta受体以及T细胞表达的疱疹病毒入口介导分子(HVEM)的配体。这里我们表明肿瘤环境中LIGHT的被动表达可以诱导大量纯真T淋巴细胞的侵润，后者与趋化因子的产生和黏附分子的表达紧密相关。这些侵润的T淋巴细胞活化可能通过HVEM，引起机体局部和末梢部位对确立的高度进展性肿瘤的抵制。我们的研究表明靶向此肿瘤屏障可能是肿瘤免疫治疗的一种有效策略。
文章连接：
http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?http://dx.doi.org/10.1038/ni1029
文题: Priming of naive T cells inside tumors leads to eradication of established tumors.
作者：Yu P, Lee Y, Liu W, Chin RK, Wang J, Wang Y, Schietinger A, Philip M, Schreiber
H, Fu YX.
杂志全名： Nature Immunology.
年份，卷（期）: 起止页码：2004 Jan 4 [Epub ahead of print].
The tumor barrier comprised of nonantigenic stromal cells may contribute to the failure of tumor rejection. The tumor-necrosis factor superfamily member LIGHT (also known as TNFSF-14) is a ligand of stromal cell-expressed lymphotoxin-betta receptor and T cell-expressed herpes viral entry mediator (HVEM). Here we show that forced expression of LIGHT in the tumor environment induces a massive infiltration of naive T lymphocytes that correlates with an upregulation of both chemokine production and expression of adhesion molecules. Activation of these infiltrating T cells, possibly through HVEM, leads to the rejection of established, highly progressive tumors at local and distal sites. Our study indicates that targeting the tumor barrier may be an effective strategy for cancer immunotherapy.
由非抗原性基质细胞构成的肿瘤屏障的形成可能归因于机体对肿瘤抵制的失败。肿瘤坏死因子超家族成员LIGHT（也称为TNFSF-14）是基质细胞表达的淋巴毒素- beta受体以及T细胞表达的疱疹病毒入口介导分子(HVEM)的配体。这里我们表明肿瘤环境中LIGHT的被动表达可以诱导大量纯真T淋巴细胞的侵润，后者与趋化因子的产生和黏附分子的表达紧密相关。这些侵润的T淋巴细胞活化可能通过HVEM，引起机体局部和末梢部位对确立的高度进展性肿瘤的抵制。我们的研究表明靶向此肿瘤屏障可能是肿瘤免疫治疗的一种有效策略。
文章连接：
http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?http://dx.doi.org/10.1038/ni1029
