病例盐酸托鲁地文拉法辛在真实世界的治疗应用一例

托鲁地文拉法辛

•以托鲁基取代文拉法辛分子中的甲基，亲脂性更强，有助于快速入脑；对DAT的亲和力更强

•临床前研究显示80mg即可抑制5-HT/NE/DA三种转运体的再摄取

文拉法辛

•低剂量有5-HT再摄取抑制作用 

•高剂量有5-HT和NE再摄取抑制作用 

•超高剂量对前额叶皮质DA有再摄取抑制作用

地文拉法辛

•5-HT/NE双重再摄取抑制

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