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Hyperthermia is generally regarded as a mean body temperature higher than normal. High body temperature is often caused by illness, such as fever or heat stroke. Research has shown that elevated body temperature can damage and kill cancerous cells with minimal injury to normal cells .The main mechanism involved is by killing the cancer cells by destructing proteins and the structure within cells. Thus, hyperthermia may shrink tumors. Hyperthermia may make some of the tumor cells more prone to radiations or damage other cancer cells which cannot be damaged by radiation. Many times, it also increases the effects of certain anticancer agents. In this study, we would focus on use of heat to treat cancer.

Hyperthermia is widely applicable with different other forms of cancer therapy, including radiation therapy and chemotherapy. The aim of the study was to treat many types of cancer including brain, liver, sarcoma, lung, esophagus, breast, bladder, rectum and peritoneal lining . There are over 100 types of cancers present in the world and are classified according to cell type. According to GLOBOCAN statistics analysis, 14.1 million new cancer cases, 8.2 million cancer deaths and 32.6 million people living with Cancer were reported. The American Cancer society in 2014 provided the annual report, according to which there will be an estimated 1,665,540 new cancer cases diagnosed . Hyperthermia is under clinical trials and is not widely available. However,while receiving those combination therapies, only few have shown increased survival in patients .Various techniques of hyperthermia are presently under investigation, that include local, regional and wholebody hyperthermia.

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原文来源如下链接：

Hyperthermia: Role and Risk Factor for Cancer Treatment - ScienceDirect