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病例PFS 近 3 年,赛沃替尼单药治疗 MET ex14 跳突 NSCLC 实现持续 PR

发布于 02-05 · 浏览 1580 · IP 浙江浙江

导语:长治久安,赛沃替尼助力 MET ex14 跳突肺癌患者拥抱正常生活。

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内容策划:方程

项目审核:杨静


参考文献:

[1]Spitaleri G, et al. MET in Non-Small-Cell Lung Cancer (NSCLC): Cross 'a Long and Winding Road' Looking for a Target. Cancers (Basel). 2023;15(19):4779.

[2]Awad MM, et al. MET Exon 14 Mutations in Non-Small-Cell Lung Cancer Are Associated With Advanced Age and Stage-Dependent MET Genomic Amplification and c-Met Overexpression. J Clin Oncol. 2016;34(7):721-30.

[3]Schoenfeld AJ, et al. Clinical and molecular correlates of PD-L1 expression in patients with lung adenocarcinomas. Ann Oncol. 2020;31(5):599-608.

[4]Negrao MV, et al. Oncogene-specific differences in tumor mutational burden, PD-L1 expression, and outcomes from immunotherapy in non-small cell lung cancer. J Immunother Cancer. 2021;9(8):e002891.

[5]Lu S, et al. Once-daily savolitinib in Chinese patients with pulmonary sarcomatoid carcinomas and other non-small-cell lung cancers harbouring MET exon 14 skipping alterations: a multicentre, single-arm, open-label, phase 2 study. Lancet Respir Med. 2021;9(10):1154-1164.

[6]张文会, 等. 肺肉瘤样癌的诊疗进展评述. 肿瘤预防与治疗. 2023;36(9):732-737.

[7]Gong C, et al. MET alterations in advanced pulmonary sarcomatoid carcinoma. Front Oncol. 2022:12:1017026.

肺肉瘤样癌 (10)
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最后编辑于 02-05 · 浏览 1580

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