翻译：成功药物透皮体系的新机理和装置

文题：Novel mechanisms and devices to enable successful transdermal drug delivery
作者：Drug Delivery Group , School of Pharmacy ,University of Bradford , Bradford BD7 1DP,UK
杂志全名： European Journal of Pharmaceutical Sciences 14 (2001) 101–114

英文摘要：Abstract
Optimisation of drug delivery through human skin is important in modern therapy. This review considers drug–vehicle interactions (drug or prodrug selection, chemical potential control, ion pairs, coacervates and eutectic systems) and the role of vesicles and particles (liposomes, transfersomes, ethosomes, niosomes).We can modify the stratum corneum by hydration and chemical enhancers, or bypass or remove this tissue via microneedles, ablation and follicular delivery. Electrically assisted methods (ultrasound, iontophoresis, electroporation, magnetophoresis, photomechanical waves) show considerable promise. Of particular interest is the synergy between chemical enhancers, ultrasound, iontophoresis and electroporation. Ó 2001 Elsevier Science B.V. All rights reserved.
Keywords : Review; Skin enhancement; Iontophoresis; Ultrasound; Liposomes

中文译文：摘要：在现代药物治疗中药物透皮体系的优化是非常重要的。本篇综述回顾了药物－载体相互作用（药物或前药部分，化学方面，离子对，团聚（体）和共晶体系）以及载体与粒子的作用（脂质体，传递体，等）机理。我们可以通过水合作用，化学促进剂，或者通过显微针头，消融移开皮肤屏障，以及通过毛囊转运而避开皮肤屏障。电学方法（超声，离子电渗等）也表现了相当的作用。化学促进剂，超声，离子电渗和电穿孔方法的协同作用具有特殊的意义。
关键词：综述；皮肤吸收促进剂；离子电渗疗法；超声；脂质体

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不好意思，原文太大，发不上来。