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这里的to表示目的吗?

发布于 2024-06-02 · 浏览 2532 · IP 江苏江苏

TLS is the most common disease-related emergency encountered by physicians caring for patients diagnosed with hematologic cancers.This occurs when tumor cells release their contents into the bloodstream leading to characteristic findings of excessive potassium phosphate, increased uric acid, and hypocalcemia (Figure 24.2).17 These abnormalities most likely occur between three days prior to and 7 days after starting chemotherapy. TLS develops most often in patients with non-Hodgkin lymphoma or acute leukemia. The clinical presentation of this syndrome is cardiac arrhythmias, seizures, renal insufficiency, and multi-system organ failure.18 Other possible symptoms of TLS include lethargy, nausea, edema, syncope, fluid overload, and heart failure. Common treatment of TLS focuses on maintaining a normal balance of electrolytes in the blood to maximize kidney function, prevent uric acid formation, and facilitate breakdown or excretion of existing uric acid.Hydration via IV is the cornerstone of TLS prophylaxis.17,18 While treating a PWC in an acute setting, paying close attention to the uric acid, calcium, and potassium lab values, in conjunction with symptom monitoring, can alert a therapist to the presence of TLS.This information would then be provided to the multidisciplinary team for further work up

肿瘤溶解综合征(Tumor Lysis Syndrome,TLS)

治疗血液系统恶性肿瘤患者时,TLS是医生最常遇到的疾病相关的紧急情况。该情况发生在肿瘤细胞释放其内容物入血液时,导致磷酸盐和钾过量、尿酸升高和低钙血症(见图24.2)17。这些异常常发生在化疗开始前的3天至化疗结束后的7天间。TLS最常见于非霍奇金淋巴瘤或急性白血病患者。该综合征的临床表现为心律失常、惊厥、肾功能不全和多系统器官衰竭18。TLS的其他可能症状包括嗜眠、恶心、水肿、晕厥、液体超负荷和心力衰竭。对于TLS的常见治疗主要集中于维持血液中电解质平衡,以最大限度地促进肾功能,预防尿酸形成,并促进现有尿酸的分解或排泄。静脉补液是预防TLS的基础17,18。在急诊治疗肿瘤患者时,密切关注尿酸、钙和钾的实验室指标值,结合症状监测,可以提醒治疗师警惕TLS,并将这些信息提供给多学科团队进一步全面评估。

接上问Common treatment of TLS focuses on maintaining a normal balance of electrolytes in the blood to maximize kidney function, prevent uric acid formation, and facilitate breakdown or excretion of existing uric acid?怎么理解?@tigger @xiaospring 这里的to表示目的吗?维持血液中电解质的正常平衡,就能最大化肾脏功能?说不通啊?

最后编辑于 2024-06-02 · 浏览 2532

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