STEM CELLS AND BREAST CANCER:A FIELD IN TRANSIT
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Matthew Smalley and Alan Ashworth.STEM CELLS AND BREAST CANCER:A FIELD IN TRANSIT.NATURE REVIEWS | CANCER VOLUME 3 | NOVEMBER 2003 | 835
Abstract：Evidence that supports the existence of a tumour stem cell for breast cancer has given fresh impetus to the search for an adult mammary epithelial stem cell in the normal breast. Such a cell might be responsible for routine tissue renewal and the massive expansion in epithelial tissue that the breast undergoes during pregnancy, and might be the cell of origin of most, if not all, breast tumours. So, what evidence is there that an adult mammary epithelial stem cell exists, what is its possible identity and what opportunities might the identification of such a cell present for the development of novel therapeutic and prophylactic strategies for treating breast cancer?
摘要翻译：有证据支持乳腺癌中存在肿瘤干细胞，这推动了在正常乳腺中寻找成年乳腺上皮干细胞的研究。这种细胞可能是乳腺组织常规更新和母体孕期乳腺上皮组织体积增大的原因，而且可能是绝大多数乳腺癌细胞来源。因此，有什么证据证明成年乳腺上皮干细胞的存在？如何确定其身份？采用新的治疗和预防措施治疗乳腺癌时，如何选择合适的时机鉴定这种细胞的存在？这篇综述对上述问题进行了讨论。
Abstract：Evidence that supports the existence of a tumour stem cell for breast cancer has given fresh impetus to the search for an adult mammary epithelial stem cell in the normal breast. Such a cell might be responsible for routine tissue renewal and the massive expansion in epithelial tissue that the breast undergoes during pregnancy, and might be the cell of origin of most, if not all, breast tumours. So, what evidence is there that an adult mammary epithelial stem cell exists, what is its possible identity and what opportunities might the identification of such a cell present for the development of novel therapeutic and prophylactic strategies for treating breast cancer?
摘要翻译：有证据支持乳腺癌中存在肿瘤干细胞，这推动了在正常乳腺中寻找成年乳腺上皮干细胞的研究。这种细胞可能是乳腺组织常规更新和母体孕期乳腺上皮组织体积增大的原因，而且可能是绝大多数乳腺癌细胞来源。因此，有什么证据证明成年乳腺上皮干细胞的存在？如何确定其身份？采用新的治疗和预防措施治疗乳腺癌时，如何选择合适的时机鉴定这种细胞的存在？这篇综述对上述问题进行了讨论。
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