[摘要翻译]CXCR4的表达与早期乳腺癌的淋巴结转移
发布于 2005-11-09 · 浏览 319 · IP 湖南湖南
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CXCR4的表达与早期乳腺癌的淋巴结转移相关
目前有研究表明CXCR4与肿瘤的转移相关，所以研究CXCR4的表达与早期乳腺癌腋窝淋巴结转移状态的关系是很有意义的。根据淋巴结转移程度将85名早期乳腺癌患者分为三组。所有受试者均用免疫组化的方法来检测CXCR4的表达，然后评价它的表达水平与腋窝淋巴结转移状态间的关系。此三组患者的核内CXCR4表达水平存在显著差异，它的核内高表达与腋窝淋巴结转移阴性相关，然而胞浆内CXCR4的高表达与腋窝淋巴结广泛转移相关。结论：不同部位CXCR4的水平反映腋窝淋巴结转移的不同状况。特别的，这里可以得出的结论是胞浆内CXCR4的高表达与腋窝淋巴结广泛转移相关，此种患者有必要辅助放疗。
Expression of CXCR4 is associated with axillary lymph node status in patients with early breast cancer.
Su YC, Wu MT, Huang CJ, Hou MF, Yang SF, Chai CY.
Breast. 2005 Oct 17; [Epub ahead of print]
Recent studies have discovered that CXCR4 is associated with tumor metastasis. It is worth understanding the association between CXCR4 expression and axillary lymph node involvement in early breast cancer. Eighty-five patients with early breast cancers were divided into three groups based on their axillary lymph node status. CXCR4 expression was assessed by immunohistochemistry in all cases and its correlation with axillary lymph node involvement was evaluated. There was a significant difference in nuclear CXCR4 expression among these three groups and high nuclear expression of CXCR4 was associated with cases with no lymph node involvement. However, high cytoplasmic expression of CXCR4 was associated with patients who developed high-level axillary lymph node involvement. In conclusion, the different staining locations of CXCR4 have varying biological significance for the metastatic potential of axillary lymph nodes. In particular, it provided information that high cytoplasmic expression of CXCR4 was related to axillary internodal metastasis, and adjuvant radio-chemotherapy was suggested.
PMID: 16239110
目前有研究表明CXCR4与肿瘤的转移相关，所以研究CXCR4的表达与早期乳腺癌腋窝淋巴结转移状态的关系是很有意义的。根据淋巴结转移程度将85名早期乳腺癌患者分为三组。所有受试者均用免疫组化的方法来检测CXCR4的表达，然后评价它的表达水平与腋窝淋巴结转移状态间的关系。此三组患者的核内CXCR4表达水平存在显著差异，它的核内高表达与腋窝淋巴结转移阴性相关，然而胞浆内CXCR4的高表达与腋窝淋巴结广泛转移相关。结论：不同部位CXCR4的水平反映腋窝淋巴结转移的不同状况。特别的，这里可以得出的结论是胞浆内CXCR4的高表达与腋窝淋巴结广泛转移相关，此种患者有必要辅助放疗。
Expression of CXCR4 is associated with axillary lymph node status in patients with early breast cancer.
Su YC, Wu MT, Huang CJ, Hou MF, Yang SF, Chai CY.
Breast. 2005 Oct 17; [Epub ahead of print]
Recent studies have discovered that CXCR4 is associated with tumor metastasis. It is worth understanding the association between CXCR4 expression and axillary lymph node involvement in early breast cancer. Eighty-five patients with early breast cancers were divided into three groups based on their axillary lymph node status. CXCR4 expression was assessed by immunohistochemistry in all cases and its correlation with axillary lymph node involvement was evaluated. There was a significant difference in nuclear CXCR4 expression among these three groups and high nuclear expression of CXCR4 was associated with cases with no lymph node involvement. However, high cytoplasmic expression of CXCR4 was associated with patients who developed high-level axillary lymph node involvement. In conclusion, the different staining locations of CXCR4 have varying biological significance for the metastatic potential of axillary lymph nodes. In particular, it provided information that high cytoplasmic expression of CXCR4 was related to axillary internodal metastasis, and adjuvant radio-chemotherapy was suggested.
PMID: 16239110
最后编辑于 2022-10-09 · 浏览 319
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