the Bottom Line？generalisability？

High flow nasal prongs

High flow nasal oxygen contributes a controllable concentration of warm humidified oxygen at some sort of uncontrollable pressure. The generic benefits of this strategy are well discussed elsewhere. How does it help in pneumonia, and what’s the evidence?

The largest and most methodologically awesome study of this specific thing was the FLORALI trial (Frat et al, 2015). The investigators’ patient group had unilateral infiltrates in 21% of cases, and were diagnosed with “pneumonia” (82%). It was essentially a study of pneumonia and high flow nasal prongs, sufficiently so that the Bottom Line complained about the poor generalisability of their findings to other sorts of ARDSish hypoxic respiratory failure. The main outcomes to look at were intubation rates

高流量鼻塞氧疗

高流量鼻氧疗提供一定程度的不可控压力、可控浓度的温湿氧气，其一般益处在其他地方已充分讨论。它对肺炎有什么帮助，证据是什么？

关于这一具体问题，规模最大和方法最优秀的研究是FLORALI试验（Frat et al,2015）。研究者的患者组中21%的病例单肺浸润，被诊断为“肺炎”（82%）。FLORALI试验本质上是对肺炎和高流量鼻塞氧疗的研究，足以使基层医务人员抱怨他们的发现对其他类型的ARDSish缺氧性呼吸衰竭的推广性较差。需要观察的主要结局是插管率。

the Bottom Line？generalisability？理解的对吗？