这3个怎么能并列呢?
Breakage of chromosomes in cultures of animal lung fibroblasts by high concentrations of oxygen was first demonstrated in 1978.7 Subsequent work has demonstrated that ROS are involved in damaging both nuclear and mitochondrial DNA, including repair errors, double-strand breaks and activation of transcription factors and signal proteins. These mechanisms are all believed to underpin the role of ROS in carcinogenesis.8In vivo studies of therapeutic hyperbaric oxygen in humans have also shown DNA damage. However, adverse clinical outcomes from hyperbaric oxygen have not been demonstrated, although susceptible subgroups that have less effective cellular antioxidant or DNA repair systems may exist.
DNA。动物肺成纤维细胞培养中,首次于1978年证实了高浓度氧会导致染色体的断裂7。随后的研究表明,ROS参与损伤细胞核和线粒体DNA,包括修复错误、双链断裂以及激活转录因子和信号蛋白。这些机制都是ROS致癌作用的基础8。高压氧治疗的体内研究也显示损伤DNA。然而,尽管可能存在细胞抗氧化或DNA修复系统效率较低的易感亚群,但尚未证实高压氧的不良临床预后[9]。
“修复错误、双链断裂以及激活转录因子和信号蛋白”,这3个怎么能并列呢?“修复错误”是好的、“双链断裂”是坏的、“激活转录因子和信号蛋白”是中性的,下面说“致癌作用”,那就应该都是坏的,但“修复错误”怎么是坏的呢?
是“修复时的错误”?repair做形容词?repair能做形容词吗?
最后编辑于 2023-02-03 · 浏览 3443