有逗号没逗号有区别吗？

Chronic kidney disease leads to a lack of renal erythropoietin release, and severe symptomatic anaemia results, with patients commonly having haemoglobin levels of less than 80 g.L21 . The availability of erythropoiesis-stimulating agents10 has allowed partial correction of anaemia in many patients, leading to a substantial improvement in quality of life for most. There is, however, debate about the optimal target haemoglobin concentration.1There is good evidence that the chronic severe anaemia associated with renal disease commonly leads to cardiac complications. Unfortunately, there is also some evidence that correction of haemoglobin to normal values is associated with increased cardiac complications in these patients, and a value of around 115 g.L21 seems to be the safest compromise.

慢性肾脏疾病会导致促红细胞生成素释放不足和严重的症状性贫血，患者的血红蛋白通常低于80g/L。得益于促红细胞生成剂¹⁰在临床中的应用，许多患者纠正了贫血，极大改善了生活质量。然而，关于最佳的目标血红蛋白浓度仍有争议¹¹。充分证据表明慢性肾性重度贫血通常会导致心脏并发症，且某些研究证实将血红蛋白浓度提升至正常范围与增加心脏并发症有关，所以目前认为将血红蛋白浓度提升至115g/L似乎是一个安全的折衷方案^10，11。

还是：

慢性肾脏疾病会导致促红细胞生成素释放不足，促红细胞生成素释放不足引起严重的症状性贫血，

有逗号没逗号有区别吗？