医学生态树，为揭示人类疾病本质提供新框架和认识

近日，国家感染性疾病临床医学研究中心/南方科技大学第二附属医院(深圳市第三人民医院)罗伟仁博士在Preprints 更新发布了V2版本“鼻咽癌生态学理论：肿瘤为多维时空生态进化合一的病理生态系统” (Nasopharyngeal Carcinoma Ecology Theory: Cancer as Multidimensional Spatiotemporal “Unity of Ecology and Evolution” Pathological Ecosystem，V1版本于10月17日发布）。

Similar to various kinds of neoplasms, other human systemic diseases, for example, cardiovascular diseases such as atherosclerosis (AS), rheumatism and infective endocarditis, respiratory diseases such as chronic obstructive pulmonary disease (COPD) and pneumoconiosis, digestive diseases include peptic ulcer, viral hepatitis-liver cirrhosis, urinary diseases include glomerulonephritis and tubulointerstitial nephritis, gynecological diseases such as cervical intraepithelial neoplasia (CIN), endocrine diseases (e.g. diabetes), and infectious diseases such as tuberculosis and syphilis, the basic pathological changes of those are that parenchymal cells adaptively interplay with their particular stromal environment such as microbiomes, immune cells and other stromal cells in the complex community. For example, an ecological and evolutionary view on human-microbe disease has been advocated (270). Moreover, increasing evidence supports a significant correlation between microorganisms and the incidence of human metabolic disorders such as AS, type 2 diabetes mellitus and non-alcoholic fatty liver disease. In a word, the occurrence, development and outcome of (most of) human diseases belongs to be a spatiotemporal ecological process (medical ecology)（人类疾病的发生发展和转归本质上可视为一个多维时空生态过程）. We believe that human “medical ecology” might have more implications than before (133,250,271,272). A novel model about medical ecology tree of human diseases is constructed （医学生态树）(Fig. 5).

学术报道

https://m.thepaper.cn/baijiahao_20920234