黏液有缺陷？

Mucociliary Clearance

Mucociliary clearance is abnormal after lung transplantation52.The cause seems to be defective production of mucus, rather than changes in the function of the cilia. This, together with the absent cough reflex below the line of the airway anastomosis, means that the patient is at a disadvantage in clearing secretions. Side effects of immunosuppression compound these changes and lead to enhanced susceptibility to infection of the transplanted lung. Although these factors clearly do not preclude long-term survival of the graft, one-quarter of deaths following lung transplantation result from infection.

纤毛清除

肺移植术后纤毛清除异常52，原因似乎是黏液有缺陷，而不是纤毛功能的改变。加上气道吻合口以下咳嗽反射消失，意味着患者清除分泌物方面障碍。免疫抑制的副作用加剧了这些变化，并导致移植肺对感染的易感性增强。虽然这些因素不会明显妨碍移植物的长期存活，但四分之一的肺移植术后的死亡是感染。

defective production of mucus黏液有缺陷？太多、太厚？