effective normalization?

Ovine septic AKI was characterized by an early onset on renal medullary tissue hypoperfusion and hypoxia, which has been previously demonstrated to precede the elevations in plasma creatinine and oliguria by 12–24 h in this large mammalian model [37–39].Following administration of mega-dose sodium ascorbate at 24 h of established Gram-negative sepsis, there was a reversal in renal medullary tissue hypoperfusion and tissue hypoxia, which was associated with a complete reversal of AKI as indicated by profound improvements in urine flow and creatinine clearance and an effective normalization in plasma creatinine (Fig. 1). Renal histopathological investigations revealed no acute tubular necrosis, interstitial fibrosis, nor birefringent oxalate crystals within the renal cortex, renal corticomedullary junction, nor renal medulla in animals treated with or without mega-dose sodium ascorbate.

绵羊脓毒血症性AKI的特征为早期发生肾髓质组织灌注不足和缺氧，之前已证实在绵羊脓毒血症性AKI模型中，肾髓质组织灌注不足和缺氧先于血浆肌酐升高和少尿12-24 h。在革兰氏阴性毒血症24h给予大剂量抗坏血酸钠后，肾髓质组织低灌注和组织缺氧逆转，这与 AKI的完全逆转相关，表现为尿流量和肌酐清除率的显著改善和血浆肌酐的有效正常化（图1）。肾组织病理学研究显示，无论是否超大剂量抗坏血酸钠给药，均无无急性肾小管坏死、间质纤维化，也无肾皮质、肾皮髓质交界处或肾髓质内双折射草酸盐晶体。

effective normalization有效正常化?好像明白，又好像不明白