怎么感觉因果关系反了？

Adequate tissue oxygenation requires appropriate delivery (DO2) to meet consumption (VO2) demands, and the extraction ratio (ERO2 = VO2/DO2) can provide a glimpse into the adequacy of that oxygen delivery. The Fick equation (CO = VO2/[CaO2-CvO2]) shows that cardiac output is directly related to oxygen consumption and inversely related to the difference in oxygen content across the arterial and venous circulations.Hence, as the difference in oxygen content between the arterial and venous circulation increases (i.e., extraction increases), cardiac output decreases. Assuming an arterial oxygen saturation of 100%, the Fick equation can be simplified to reflect that the SvO2 = 1-extraction ratio . A critical extraction threshold (ERO2crit) in healthy patients is 0.7 (SvO2 of 30%), at which point tissue perfusion is likely inadequate, and anaerobic metabolism (i.e., lactate production) commences. In stressed patients, (i.e., septic shock), this critical extraction threshold is closer to an SvO2 of 50%. Conversely, elevated SvO2 (>85%) may represent high cardiac output, or more ominously, microcirculatory shunting or impaired tissue extraction. Likely multifactorial in etiology, regional differences in auto-regulation, interstitial edema, liposomal dysfunction and injury, and mitochondrial dysfunction all likely contribute to the decreased extraction capacity in stressed patients.

充分的组织氧合需要适当的氧输送(DO2)以满足消耗(VO2)需求，摄取率(ERO2 = VO2/DO2)可以提供该氧输送是否充分的大约了解。Fick方程（CO = VO2/[CaO2-CvO2]）显示，心输出量与耗氧量直接相关，与动脉和静脉循环中氧含量差呈负相关。因此，随着动脉和静脉循环之间氧含量差增加（即摄取增加），心输出量下降。假设动脉血氧饱和度为100%，Fick方程可以简化为反映SvO2=1-摄取率。健康病人的临界摄取率阈值（ERO_2crit）为0.7（SvO2为30%），达到临界摄取率阈值时，组织灌注可能不足，无氧代谢（即乳酸产生）开始。在应激（即脓毒症休克）患者中，这个临界摄取率值使得SvO2更接近于50%。相反，SvO2升高（>85%）可能代表高心输出量，或者更不祥的是，微循环分流或组织摄氧功能受损。可能是多因素的病因（自动调节的区域差异、间质水肿、脂质体功能障碍和损伤以及线粒体功能障碍）都可能导致应激患者的摄氧能力下降。

1.as the difference in oxygen content between the arterial and venous circulation increases (i.e., extraction increases), cardiac output decreases.因此，随着动脉和静脉循环之间氧含量差增加（即摄取增加），心输出量下降。

怎么感觉因果关系反了，应该是“随着心输出量下降，动脉和静脉循环之间氧含量差增加（即摄取增加），”

2.脂质体功能障碍和损伤指什么？