individualize与in patients对应的吧？

MAP levels over the autoregulatory range does not result in further changes in perfusion, but the issue of the optimal value is controversial, and a higher MAP may be beneficial in chronic hypertensive patients with shock and microcirculatory dysfunction. However, there are some contradictory data, particularly in elderly patients.Thus, more research is clearly required on the best way to individualize MAP target by taking into consideration the effects on systemic, regional and eventually microcirculatory flow especially in patients with septic shock [4].

MAP水平超过自身调节范围不会导致灌注的进一步变化，但最佳值尚有争议，较高的MAP可能对慢性高血压患者的休克和微循环功能障碍有益。然而，数据有些矛盾，特别是在老年患者中。因此，通过考虑对全身、局部和最终微循环血流的影响，显然需要对设定最佳个体化（尤其对于脓毒症休克患者）的MAP目标进行更多研究。

individualize与in patients对应的吧？所以应该合并翻译吧？