什么叫“囊性纤维化与胰管相似”？

In patients with cysticfibrosis, metabolic alkalosis could be the initial presentation in infants and children. Very recent studies have indicated that similar to the pancreatic duct, the hormone secretin can function as an agonist to activate renal HCO3− secretion via the Cl−/HCO3− exchanger pendrin in B-intercalated cells. Given the specific role of pendrin downregulation in the pathogenesis of metabolic alkalosis in cysticfibrosis, the term“distal renal tubular alkalosis” was proposed to encompass those disturbances that cause metabolic alkalosis through reduced HCO3− secretion from the collecting duct.

囊性纤维化的婴儿和儿童中，代谢性碱中毒可能是首发表现。最近的研究表明，囊性纤维化与胰管相似，促激素分泌释放激素可作为激动剂通过B闰细胞中的Cl^-/HCO₃^-交换体pendrin激活肾脏HCO₃^-分泌。鉴于pendrin下调在囊性纤维化代谢性碱中毒发病机制中的具体作用，提出术语“远端肾小管碱中毒”包括通过集合管HCO₃^-分泌减少引起代谢性碱中毒的紊乱。

https://www.doc88.com/p-0087227066490.html

什么叫“囊性纤维化与胰管相似”？谢谢