respectively指什么？

Recent studies have identified kidney-specific mechanisms that contribute to the generation of metabolic alkalosis in the setting of volume contraction. These reports demonstrated that pendrin, which is critical to Cl− absorption (and HCO3− secretion) by B-intercalated cells in volume-depleted states, is profoundly downregulated in cysticfibrosis.a Pendrin downregulation impairs the ability of the kidney collecting duct to absorb salt and enhance HCO3− secretion (Fig 1). This further exacerbates the magnitude of volume contraction and metabolic alkalosis due to renal Cl− loss and impaired HCO3− secretion into the collecting duct, respectively. The loss of Cl− in the urine consequent to the inactivation of pendrin in the setting of volume depletion mimics a pseudo-Bartter picture, which has been described in cysticfibrosis patients.

最近的研究已经确定了容量下降时，代谢性碱中毒的肾脏特异性机制。这些研究表明，pendrin（在容量耗尽时对B闰细胞吸收Cl^-和泌HCO₃^-至关重要）在囊性纤维化时显著下调。Pendrin下调损害了肾脏集合管吸收盐和增强HCO₃^-分泌的能力（图1）。进一步分别加剧了容量降低和因肾脏Cl^-丢失和HCO₃^-分泌到集合管受损导致的代谢性碱中毒的幅度。在容量耗竭时，pendrin失活导致的尿液中Cl^-的丢失类似假性巴特综合征，假性巴特综合征在囊性纤维化患者中已有描述

respectively指什么？指“volume contraction and metabolic alkalosis ”还是“renal Cl− loss and impaired HCO3− secretion ”？

mimics a pseudo-Bartter picture？类似假性巴特综合征？

谢谢