修饰/指代没搞清楚？

Current trends in ARDS research involve devising strategies based upon recent advances in our understanding. This includes varied clinical presentations such as lobar vs. diffuse lung injury, severity of hypoxemia, and most recently the interactions between proinflammatory mediators with markers of endothelial dysfunction that distinguish early resolution from persistent hypoxemia.Newer still is examining specific gene expression governing inflammation that might provide a more comprehensive understanding of ARDS, and also the possibility for highly specific novel drug therapies for certain ARDS phenotypes, or perhaps targeting current therapies more effectively. Research in this area already has discerned ARDS subphenotypes associated with the spectrum of inflammatory response (ie. uninflamed, reactive, hyporeactive and hyperreactive) suggesting the existence of “treatable traits” with implications beyond ARDS.The hoped-for result is developing more “personalized medicine” for the treatment of ARDS and other critical illnesses.

This\Newer 应该都是指research？

that distinguish early resolution from persistent hypoxemia修饰什么？修饰clinical presentations还是interactions还是dysfunction

目前ARDS研究的趋势是在我们理解的最新进展的基础上制定策略。这些研究包括不同的临床表现（如大叶性与弥漫性肺损伤、低氧血症的严重程度，以及最近促炎症介质与内皮功能障碍标记物间的相互作用），以区分早期缓解与持续性低氧血症。更新的研究仍在研究控制炎症的特定基因表达，这可能为ARDS提供更全面的理解，也可能为某些ARDS表型提供高度特异性的新型药物治疗，或者可能更有效地靶向当前的治疗。该领域的研究已经发现了与炎症反应谱（即无炎症、反应性、低反应性和高反应性）相关的ARDS亚型，表明在ARDS以外具有有意义的“可治疗特征”。这一预期的结果是为治疗ARDS和其他重大疾病开发出更多的“个性化药物”。