理解的对吗？

However, the negative impact of spontaneous breathing may depend upon the underlying severity of acute lung injury.119 In the aforementioned preclinical model, spontaneous breathing during mild lung injury occurred at both a lower Pplat and lower effort causing dorsal lung recruitment with improved oxygenation and little histological impact (compared to passive ventilation). In contrast, severe lung injury stimulated greater spontaneous effort at a higher baseline Pplat that (paradoxically) promoted cyclical derecruitment worsening both oxygenation and lung injury compared passive ventilation (see below). Preclinical models also observed “occult Pendelluft” motion wherein diaphragmatic contraction redistributes alveolar volume away from non-dependent to dependent lung regions causing paradoxical overdistension of dependent lung without changing delivered VT

然而，自主呼吸的负面影响可能取决于急性肺损伤潜在的严重程度。在上述临床前模型中，轻度肺损伤期间在较低Pplat和较低吸气努力下进行自主呼吸，导致背侧肺复张，氧合改善，比被动通气对组织学的影响小。相反，严重肺损伤时在更高的基线Pplat上刺激了更大的自主呼吸努力，与被动呼吸相比，这种自主呼吸的努力矛盾地促进了周期性坍陷，加剧了氧合和肺损伤(见下文)。临床前模型也观察到“隐匿性的摆动呼吸”运动，其中膈肌收缩将肺泡通气从非重力依赖性肺区重新分配到重力依赖性肺区，导致不改变的VT前提下，重力依赖性肺区的反而得到过度扩张

理解的对吗？谢谢