显著症状的非严重疾病？

Although a significant portion of benign tracheal stenoses are caused by systemic inflammatory disorders with available medical treatments, it is crucial to avoid delays in therapeutic procedures while instituting the most appropriate systemic therapy. Patients who should be evaluated for potential airway procedures by interventional pulmonologists are (1) patients with critical tracheal stenosis who require a prompt stabilization, (2) patients with inoperable or non-severe disease with significant symptoms, and (3) patients with mostly intraluminal lesions rather than extrinsic compression. However, even patients who are good surgical candidates should be evaluated if a “bridge therapy” is needed prior to a definitive surgery or to assess surgical candidacy such as with TBM.

尽管相当一部分良性气管狭窄是由可通过现有药物治疗的全身炎症性疾病引起的，但在开始最合适的全身治疗时，避免治疗延迟至关重要。应由介入肺科医师评估潜在气道手术的患者为(1)需要迅速稳定的严重气管狭窄、(2)无法手术或有显著症状的非严重疾病、以及(3)主要为腔内病变而非外源性压迫。但是，即使有良好的手术适应征，也应在确定性手术前评估是否需要“桥接治疗”或评估拟手术患者是否有TBM。

patients with inoperable or non-severe disease with significant symptoms无法手术或有显著症状的非严重疾病？理解的对吗？

有显著症状的非严重疾病？这么翻译合适吗？有显著症状的非恶性疾病？severe这里翻译成恶性可以吗？