劲爆新发现，SCIENCE发文提出新的细胞死亡形式，铁死亡还没追上，铜死亡又来了

近期，Todd R. Golub课题组揭示了一种新的细胞死亡形式，即铜死亡，铜毒性涉及特定线粒体代谢酶的破坏，从而引发一种不寻常的细胞死亡机制。

该机制解读了遗传性铜过载疾病相关的病理学，并提出利用铜毒性治疗癌症的新方法。

相关论文《Copper induces cell death by targeting lipoylated TCA cycle proteins

》发表在Science上。

有时候不是崇洋媚外，什么时候，也很期待，我国科学家，我是说生物医药领域大牛科学家，能发现类似的新的突破，可以引领学科方向。

多余的就不说了，下附论文摘要，感兴趣的朋友一起研究：

Abstract

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown. Here, we show in human cells that copper-dependent, regulated cell death is distinct from known death mechanisms and is dependent on mitochondrial respiration. We show that copper-dependent death occurs by means of direct binding of copper to lipoylated components of the tricarboxylic acid (TCA) cycle. This results in lipoylated protein aggregation and subsequent iron-sulfur cluster protein loss, which leads to proteotoxic stress and ultimately cell death. These findings may explain the need for ancient copper homeostatic mechanisms.