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solvent/detergent plasma?

发布于 2022-03-04 · 浏览 464 · IP 江苏江苏
这个帖子发布于 3 年零 66 天前,其中的信息可能已发生改变或有所发展。

Although plasma is used extensively in the treatment of bleeding patients, evidence from randomized controlled trials comparing its effect with that of other therapeutic interventions is currently lacking [29, 45]. Transfusion of FFP is frequently ineffective for correction of the outcome-related pathologies of bleeding, hypofibrinogenemia, low fibrin polymerization, and poor clot strength [46]. Nevertheless, plasma is recommended by multiple international guidelines, especially for massive transfusions [29, 47]. This requires at least 30 mL/kg body weight (BW) at 30–50 mL/min [47]. Plasma was inferior in a prospective randomized study as compared to a coagulation factor-based resuscitation strategy [46]. It is known that freezing and thawing reduces the concentration of coagulation factors by approximately 10% and that pathogen-inactivation causes additional impairment of certain plasma components [29, 48]. Whether the clinical effects of FFP, freeze-dried plasma, and solvent/detergent plasma are comparable remains to be proven [49, 50].

虽然血浆被广泛用于出血患者的治疗,但与其他治疗比较,目前缺乏随机对照研究的证据。FFP输注对于纠正出血、低纤维蛋白原血症、低纤维蛋白聚合和血凝块强度不佳等与预后相关的病理常常无效。然而,多项国际指南推荐使用血浆,尤其在大量输血时。这需要在30~50毫升/分钟的速度下输注至少30毫升/千克理想体重。在一项前瞻性随机研究中,与基于凝血因子的复苏策略相比,血浆疗效较差。众所周知,冷冻和解冻会使凝血因子的浓度降低约10%,病原体灭活又会对某些血浆成分造成额外的损害。FFP、冻干血浆和溶酶/洗涤血浆的临床效果是否相当还有待证实。

solvent/detergent plasma怎么翻译?谢谢

最后编辑于 2022-03-04 · 浏览 464

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