这几个地方都吃不准？谢谢

Our recommendations allow for personal preferences and active participation of fully informed patients, in conjunction with physician judgment (based on knowledge, experience, acumen, and intuition) to resolve ambiguities by medical reasoning that inevitably surround treatment decisions for a nuanced disease like HCM, which unavoidably relies largely on nonrandomized data from observational registries.

我们建议允许患者在充分知情下的个人偏好和积极参与，结合医生（基于知识、经验、敏锐和直觉）的判断，通过必要的围绕HCM等罕见疾病的治疗决策进行医学推理来解决争义，这就不可避免地很大程度上依赖于观察性登记研究的非随机数据。

这几个地方都吃不准？谢谢

of fully informed 充分知情下的？

ambiguities争义？

inevitably 必要的？

nuanced disease罕见疾病？