没看明白

Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian system in sepsis pathology could be an important tool to improve patient therapies.

脓毒症是一种由宿主对感染的反应失调引起的综合征，是感染致死的主要原因。在动物模型中，死亡率强烈依赖于脓毒症开始的时间，提示昼夜节律系统是个主要作用。在脓毒症治疗的患者中，也有昼夜节律失调的报道。在这里，我们回顾与脓毒症开始时间相关的数据，以进一步了解在患者和动物模型中观察到的不同预后。免疫激活的程度以及体温过低的反应与预后最差的时间相关。不同的预后似乎取决于时钟基因Bmal1在肝脏和髓系免疫细胞中的表达。了解昼夜节律系统在脓毒症病理中的作用可能是改善患者治疗的重要工具。

老师，The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis.免疫激活的程度以及体温过低的反应与预后最差的时间相关？总觉得怪怪的，感觉是不是这样

“免疫激活的程度、体温过低的反应和预后与不同的时相相关。”谢谢

the time of the worst prognosis啥意思？