理解的对吗？谢谢

Indeed, chronic pain is a significant health and economic burden and remains difficult to manage. Spine pain is a major category of chronic pain conditions. For example, patients’ description of radiating back pain is often vague and indiscriminative, so are radiological findings, to differentiate between radicular spine pain due to inflammatory irritation or compression of spinal nerve and/or DRG and pseudo- radicular pain that are not caused by such changes. For example, epidural steroid injection (ESI) is the most commonly performed interventional procedure for radiating spine pain treatment, in addition to non-procedural modalities such as physical therapy, costing $743 million per year for Medicare plans only [8]. While ESI often works well for patients with radicular pain, at least temporarily, it is much less effective or ineffective for those with pseudo-radicular pain [9–15]. Severe complications can occur with ESI as well [16, 17]. For patients with pseudo-radicular spine pain, other interventions such as lumbar facet or sacroiliac joint injections might be more effective. Indeed, clinicians often find it difficult to predict response to current modalities of spine pain care, particularly interventional procedures [18].

慢性疼痛的确对健康和经济产生巨大负担，且仍然难以管理，脊柱疼痛是慢性疼痛的一大类。例如，对于炎症刺激或压迫神经根和/或DRG导致的以下肢放射性疼痛为表现的神经根痛，无论患者对症状的描述还是影像学往往都是模糊和难以区别的，这就与非炎症刺激或压迫导致的假性神经根性痛相不同。再比如，除物理治疗等非手术治疗方式外，硬膜外类固醇注射(epidural steroid injection，ESI)是治疗下肢放射痛最常用的介入治疗手段，每年仅医疗保险花费就高达7.43亿美元^[8]。虽然ESI通常对根性疼痛患者有效，至少暂时有效，但对假性根性疼痛患者疗效微著或无效^[9-15]。ESI也可能出现严重的并发症^[16,17]。对于假性根性疼痛患者，腰椎小关节或骶髂关节注射等其它干预措施可能更有效。事实上，临床医生往往很难预测目前脊柱疼痛治疗模式的疗效，尤其是介入治疗^[18]。

理解的对吗？谢谢