丁卡因治疗恶性高热的可能性
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恶性高热的特效药丹曲林钠机制是抑制ryanodine受体，丁卡因在老鼠中证明也有剂量依赖的类似效应，在国内没有丹曲林钠的现实下，万一遇到恶性高热，除了常规的处理外，在无法获得特效药的情况下，能否用丁卡因来救急。Tetracaine is rarely used today outside of topical applications for short ENT and ophthalmologic procedures. It has been studied on rat models and found to additionally function via a dose-dependent inhibition of intracellular calcium release through ryanodine receptors. This pharmacology has not been studied in humans but may be of some interest as this mechanism is similar to that of dantrolene for use in treating malignant hyperthermia.[13]
