【共享】研究揭示晕动症的遗传基因
发布于 2015-02-05 · 浏览 1260 · IP 北京北京
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Study uncovers genetics of motion sickness
研究揭示晕动症的遗传基因
23andMe公司公布了晕动症全基因组的首个相关性研究。这项研究结果发表在牛津《人类分子遗传学》（Human Molecular Genetics）杂志上。该研究首次确认了与晕动症有关的遗传变异（每三个人中就有一人受晕动症影响）。晕动症已被证明具有较高的遗传性，这意味着遗传因素在很大程度上能够解释为什么一些人比其他人更容易受晕动症影响。据估计，70%左右的晕动症风险差异是由遗传基因不同导致的。研究人员Bethann Hromatka称，“虽然晕动症很常见，但目前我们对晕动症的遗传因素了解很少。在23andMe公司客户的帮助下，我们已经发现了一些潜在的晕动症遗传基因。这些发现有助于为晕动症和其它相关症状的病因及治疗方法提供线索，这非常令人兴奋。”
23andMe, Inc. today announced the publication of the first ever genome-wide association study of motion sickness.
Published in Oxford Journals' Human Molecular Genetics, this study is the first to identify genetic variants associated with motion sickness, a condition that affects roughly one in three people. Motion sickness has been shown to have high heritability, meaning genetics accounts for a large part of why some are more prone to motion sickness than others. Estimates indicate that up to 70 percent of variation in risk for motion sickness is due to genetics.
"Until now there's been a poor understanding of the genetics of motion sickness, despite it being a fairly common condition," said 23andMe Scientist Bethann Hromatka, lead author of the study. "With the help of 23andMe customers we've been able to uncover some of the underlying genetics of this condition. These findings could help provide clues about the causes of motion sickness and other related conditions, and how to treat them, which is very exciting."
The study, which involved the consented participation of more than 80,000 23andMe customers, found 35 genetic factorsassociated with motion sickness at a genome-wide significant level. Many of these factors, referred to as single-nucleotide polymorphisms (SNPs), are in or near genes involved in balance, and eye, ear, and cranial development (e.g., PVRL3, TSHZ1, MUTED, HOXB3, HOXD3). Other SNPs may affect motion sickness through nearby genes with roles in the nervous system, glucose homeostasis, or hypoxia. The study shows that several of these SNPs display sex-specific effects, with up to three times stronger effects in women.
The work also confirmed previously known links with other conditions, finding that people with motion sickness are more likely to have experienced migraines, vertigo, and morning sickness as well as postoperative nausea and vomiting (PONV). The study also found new phenotypic associations between motion sickness and altitude sickness as well as many gastrointestinal conditions. Two of these related conditions (PONV and migraines) were found to share underlying genetic factors with motion sickness.
The results point to the importance of the nervous system in motion sickness and suggest a role for glucose levels in motion-induced nausea and vomiting—a finding that may provide insight into other nausea-related conditions like PONV. Because the study also identified associations between motion sickness and lifestyle—for instance, there is an association between being a poor sleeper and having a propensity for motion sickness—the findings could also help researchers identify risk factors for the condition and future treatments.
本资源来自《医学新闻&文献关联与评价数据库》
研究揭示晕动症的遗传基因
23andMe公司公布了晕动症全基因组的首个相关性研究。这项研究结果发表在牛津《人类分子遗传学》（Human Molecular Genetics）杂志上。该研究首次确认了与晕动症有关的遗传变异（每三个人中就有一人受晕动症影响）。晕动症已被证明具有较高的遗传性，这意味着遗传因素在很大程度上能够解释为什么一些人比其他人更容易受晕动症影响。据估计，70%左右的晕动症风险差异是由遗传基因不同导致的。研究人员Bethann Hromatka称，“虽然晕动症很常见，但目前我们对晕动症的遗传因素了解很少。在23andMe公司客户的帮助下，我们已经发现了一些潜在的晕动症遗传基因。这些发现有助于为晕动症和其它相关症状的病因及治疗方法提供线索，这非常令人兴奋。”
23andMe, Inc. today announced the publication of the first ever genome-wide association study of motion sickness.
Published in Oxford Journals' Human Molecular Genetics, this study is the first to identify genetic variants associated with motion sickness, a condition that affects roughly one in three people. Motion sickness has been shown to have high heritability, meaning genetics accounts for a large part of why some are more prone to motion sickness than others. Estimates indicate that up to 70 percent of variation in risk for motion sickness is due to genetics.
"Until now there's been a poor understanding of the genetics of motion sickness, despite it being a fairly common condition," said 23andMe Scientist Bethann Hromatka, lead author of the study. "With the help of 23andMe customers we've been able to uncover some of the underlying genetics of this condition. These findings could help provide clues about the causes of motion sickness and other related conditions, and how to treat them, which is very exciting."
The study, which involved the consented participation of more than 80,000 23andMe customers, found 35 genetic factorsassociated with motion sickness at a genome-wide significant level. Many of these factors, referred to as single-nucleotide polymorphisms (SNPs), are in or near genes involved in balance, and eye, ear, and cranial development (e.g., PVRL3, TSHZ1, MUTED, HOXB3, HOXD3). Other SNPs may affect motion sickness through nearby genes with roles in the nervous system, glucose homeostasis, or hypoxia. The study shows that several of these SNPs display sex-specific effects, with up to three times stronger effects in women.
The work also confirmed previously known links with other conditions, finding that people with motion sickness are more likely to have experienced migraines, vertigo, and morning sickness as well as postoperative nausea and vomiting (PONV). The study also found new phenotypic associations between motion sickness and altitude sickness as well as many gastrointestinal conditions. Two of these related conditions (PONV and migraines) were found to share underlying genetic factors with motion sickness.
The results point to the importance of the nervous system in motion sickness and suggest a role for glucose levels in motion-induced nausea and vomiting—a finding that may provide insight into other nausea-related conditions like PONV. Because the study also identified associations between motion sickness and lifestyle—for instance, there is an association between being a poor sleeper and having a propensity for motion sickness—the findings could also help researchers identify risk factors for the condition and future treatments.
本资源来自《医学新闻&文献关联与评价数据库》
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