【共享】生活节律的改变会影响肠道微生态
发布于 2014-06-09 · 浏览 630 · IP 广东广东
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最近美国芝加哥与荷兰科学家通过小鼠动物实验证实，生活节律的改变会影响肠道微生态：肠道微生态失衡与生物节律紊乱都与一些类似疾病相关，包括肥胖、代谢综合征以及炎症性肠病。除了有交集外，生物节律无规律与肠道微生态失衡之间的内在关系尚不明了；因此该研究采用慢性节律干扰模型用以测定对肠道微生物组的影响。雄性C57BL/6J小鼠进行一周一次时间的光照/黑暗循环交替（也就是生物节律扰乱小鼠）来测定生物节律紊乱对肠道微生物群的影响，并通过喂食标准饮食或是高脂、高糖饮食来测定饮食是如何影响诱发生物节律紊乱后的肠道微生物。一周为周期的白天黑夜循环（LD）对喂食普通饮食的小鼠肠道微生物群没有影响；但是喂食高脂、高糖饮食结合白天黑夜循环转换的小鼠的微生物群发生了明显改变。虽然尚未确定是肠道微生态失衡介导的人类生物节律紊乱相关性不良影响（例如倒班工人、跨时区的旅行者以及与社会有时差的个人），但该研究表明生物节律紊乱能够影响可能引发炎症性疾病的肠道微生物。
Abstract
Intestinal dysbiosis and circadian rhythm disruption are associated with similar diseases including obesity, metabolic syndrome, and inflammatory bowel disease. Despite the overlap, the potential relationship between circadian disorganization and dysbiosis is unknown; thus, in the present study, a model of chronic circadian disruption was used to determine the impact on the intestinal microbiome. Male C57BL/6J mice underwent once weekly phase reversals of the light:dark cycle (i.e., circadian rhythm disrupted mice) to determine the impact of circadian rhythm disruption on the intestinal microbiome and were fed either standard chow or a high-fat, high-sugar diet to determine how diet influences circadian disruption-induced effects on the microbiome. Weekly phase reversals of the light:dark (LD) cycle did not alter the microbiome in mice fed standard chow; however, mice fed a high-fat, high-sugar diet in conjunction with phase shifts in the light:dark cycle had significantly altered microbiota. While it is yet to be established if some of the adverse effects associated with circadian disorganization in humans (e.g., shift workers, travelers moving across time zones, and in individuals with social jet lag) are mediated by dysbiosis, the current study demonstrates that circadian disorganization can impact the intestinal microbiota which may have implications for inflammatory diseases.
饮食和生物节律紊乱对小鼠肠道微生态的影响
生物节律紊乱对体重有明显影响
RESEARCH ARTICLE
Circadian Disorganization Alters Intestinal Microbiota
Abstract
Intestinal dysbiosis and circadian rhythm disruption are associated with similar diseases including obesity, metabolic syndrome, and inflammatory bowel disease. Despite the overlap, the potential relationship between circadian disorganization and dysbiosis is unknown; thus, in the present study, a model of chronic circadian disruption was used to determine the impact on the intestinal microbiome. Male C57BL/6J mice underwent once weekly phase reversals of the light:dark cycle (i.e., circadian rhythm disrupted mice) to determine the impact of circadian rhythm disruption on the intestinal microbiome and were fed either standard chow or a high-fat, high-sugar diet to determine how diet influences circadian disruption-induced effects on the microbiome. Weekly phase reversals of the light:dark (LD) cycle did not alter the microbiome in mice fed standard chow; however, mice fed a high-fat, high-sugar diet in conjunction with phase shifts in the light:dark cycle had significantly altered microbiota. While it is yet to be established if some of the adverse effects associated with circadian disorganization in humans (e.g., shift workers, travelers moving across time zones, and in individuals with social jet lag) are mediated by dysbiosis, the current study demonstrates that circadian disorganization can impact the intestinal microbiota which may have implications for inflammatory diseases.
饮食和生物节律紊乱对小鼠肠道微生态的影响
生物节律紊乱对体重有明显影响
RESEARCH ARTICLE
Circadian Disorganization Alters Intestinal Microbiota
- Robin M. Voigt mail,
- Christopher B. Forsyth,
- Stefan J. Green,
- Ece Mutlu,
- Phillip Engen,
- Martha H. Vitaterna,
- Fred W. Turek,
- Ali Keshavarzian
- Published: May 21, 2014
- DOI: 10.1371/journal.pone.0097500
最后编辑于 2022-10-09 · 浏览 630
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