【medical-news】JID:全病毒H5N1疫苗在儿童中安全有效

Background.?Children are highly vulnerableto infection with novel influenza viruses. It is essential to develop candidatepandemic influenza vaccines which are safe and effective in the pediatricpopulation.
Methods.?Infants and children aged 6-35months and 3-8 years were randomized to receive two immunizations with a 7.5 ?gor 3.75 ?g hemagglutinin (HA) dose of a non-adjuvanted whole-virus A/Vietnamstrain H5N1 vaccine; adolescents aged 9-17 years received a 7.5 ?g dose only. Asubset of participants received a booster immunization with an A/Indonesiastrain H5N1 vaccine approximately one year later. HA and neuraminidase antibodyresponses were assessed.
Results.?Vaccination was safe andwell-tolerated; adverse reactions were transient and predominantly mild. Twoimmunizations with the 7.5 ?g dose of A/Vietnam vaccine induced virusneutralization (MN) titers ≥1:20 against the A/Vietnam strain in 68.8% to 85.4% of participantsin the different age groups. After the booster, 93.1% to 100% of participantsachieved MN titers ≥1:20 against the A/Vietnam and A/Indonesia strains. NA-inhibitingantibodies were induced in ≥90% of participants after two immunizations with the 7.5 ?gA/Vietnam vaccine and in 100% of participants after the booster.
Conclusions.?A whole-virus H5N1 vaccine issuitable for pre-pandemic or pandemic immunization in a pediatric population.