【medical-news】J HEPATOL：HBsAg水平和白介素-28B基因型可预测尿毒症患者HCV的自发清除率
发布于 2013-10-03 · 浏览 911 · IP 上海上海
这个帖子发布于 11 年零 224 天前，其中的信息可能已发生改变或有所发展。
lightningwing +2丁当High hepatitis B virus surface antigen levels and favorable interleukin 28B genotype predict spontaneous hepatitis C virus clearance in uremic patients
Abstract
Background& aims
Host and viral factors interplay in the spontaneous clearance of hepatitis C virus (HCV) infection. We aimed to explore the roles of interleukin-28B genotypes and hepatitis B virus (HBV) infections in spontaneous HCV seroclearance.
Methods
Interleukin-28B rs8099917 genotypes, HCV and HBV markers were determined in 290 patients who were seropositive for HCV antibodies from 1681 total uremic patients on maintenance hemodialysis.
Results
Persistent HCV viremia was observed in 74.6% (214/287) of patients. Logistic regression revealed that the strongest factors associated with spontaneous HCV seroclearance were carriage of rs8099917 TT-type (odds ratio/ 95% confidence intervals [OR/CI]: 6.22/1.41-27.35, P=0.016), followed by concurrent hepatitis B surface antigen (HBsAg) seropositivity (OR/CI: 2.37/1.06-5.26, P=0.035). The clearance rate was highest among patients with both positive-HBsAg/rs8099917 TT-type (44.8%, OR/CI: 20.88/3.5-402.5), followed by positive-HBsAg/rs8099917 non-TT-type (28.6%, OR/CI: 8.86/1.8-160.8), and negative-HBsAg/rs8099917 TT-type (26.7%, OR/CI: 12.75/1.0-319.4), compared to 4% of negative-HBsAg/rs8099917 non-TT-type (trend P=0.0002). HBsAg levels, but not HBV DNA levels, were significantly associated with spontaneous HCV seroclearance. Spontaneous HCV seroclearance rate was 58.3% in patients with HBsAg >200 IU/mL/rs8099917 TT-type (OR/CI: 42.54/5.7-908.4), 28.0% in patients with HBsAg <200 IU/mL/rs8099917 TT-type or HBsAg >200 IU/mL/rs8099917 non-TT-type (OR/CI: 11.12/2.3-201.0), compared to only 3.3% in those with HBsAg <200 IU/mL/rs8099917 non-TT-type (trend P=0.0004). Five of 214 (2.3%) HCV viremic patients at enrollment had spontaneous HCV seroclearance during one-year follow-up, which was associated with baseline HCV RNA and HBsAg levels.
Conclusions
High HBsAg levels and favorable interleukin-28B genotype were additively associated with spontaneous HCV seroclearance in uremic patients.
Abstract
Background& aims
Host and viral factors interplay in the spontaneous clearance of hepatitis C virus (HCV) infection. We aimed to explore the roles of interleukin-28B genotypes and hepatitis B virus (HBV) infections in spontaneous HCV seroclearance.
Methods
Interleukin-28B rs8099917 genotypes, HCV and HBV markers were determined in 290 patients who were seropositive for HCV antibodies from 1681 total uremic patients on maintenance hemodialysis.
Results
Persistent HCV viremia was observed in 74.6% (214/287) of patients. Logistic regression revealed that the strongest factors associated with spontaneous HCV seroclearance were carriage of rs8099917 TT-type (odds ratio/ 95% confidence intervals [OR/CI]: 6.22/1.41-27.35, P=0.016), followed by concurrent hepatitis B surface antigen (HBsAg) seropositivity (OR/CI: 2.37/1.06-5.26, P=0.035). The clearance rate was highest among patients with both positive-HBsAg/rs8099917 TT-type (44.8%, OR/CI: 20.88/3.5-402.5), followed by positive-HBsAg/rs8099917 non-TT-type (28.6%, OR/CI: 8.86/1.8-160.8), and negative-HBsAg/rs8099917 TT-type (26.7%, OR/CI: 12.75/1.0-319.4), compared to 4% of negative-HBsAg/rs8099917 non-TT-type (trend P=0.0002). HBsAg levels, but not HBV DNA levels, were significantly associated with spontaneous HCV seroclearance. Spontaneous HCV seroclearance rate was 58.3% in patients with HBsAg >200 IU/mL/rs8099917 TT-type (OR/CI: 42.54/5.7-908.4), 28.0% in patients with HBsAg <200 IU/mL/rs8099917 TT-type or HBsAg >200 IU/mL/rs8099917 non-TT-type (OR/CI: 11.12/2.3-201.0), compared to only 3.3% in those with HBsAg <200 IU/mL/rs8099917 non-TT-type (trend P=0.0004). Five of 214 (2.3%) HCV viremic patients at enrollment had spontaneous HCV seroclearance during one-year follow-up, which was associated with baseline HCV RNA and HBsAg levels.
Conclusions
High HBsAg levels and favorable interleukin-28B genotype were additively associated with spontaneous HCV seroclearance in uremic patients.
最后编辑于 2013-10-03 · 浏览 911
2 收藏点赞
