【medical-news】JID：成人的HEV感染与HIV和环境性肠病相关

Background.?Hepatitis E virus (HEV)infection causes major epidemics of infectious hepatitis, with high mortalityrates in pregnant women. Recent reports indicate that HEV coinfections withhuman immunodeficiency virus (HIV) may have a more protracted course. However,the impact of HEV infections in communities heavily affected by HIV remainspoorly studied. We set out to examine age-related seroprevalence in a communitywhere we have previously carried out studies on environmental enteropathy.
Methods.?Blood samples from 194 childrenand 106 adults were examined for immunoglobulin G and immunoglobulin Mantibodies for HEV. HEV data were correlated with HIV status and morphometricanalysis of small intestinal biopsies.
Results.?Seroprevalence rose throughoutchildhood, from 8% in children aged 1-4 years, to 36% in children aged 10-14years. In adults, the overall prevalence was 42%, with 28% in HIV-seronegativeadults and 71% in HIV-seropositive adults (odds ratio, 6.2; 95% confidenceinterval, 2.2-18; P = .0001). In adults, villous height and crypt depthmeasurements showed that HEV seropositivity was associated with worseenteropathy (P = .05 and P = .005, respectively).
Conclusions.?HEV infection is common inZambia. In adults it is strongly associated with HIV status, and also withenvironmental enteropathy.