[摘要翻译] 副鼻窦癌放射治疗长期疗效
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英文摘要链接：
http://www.redjournal.org/article/PIIS036030160302457X/abstract
文题：Carcinoma of paranasal sinuses: long-term outcomes with radiotherapy
作者：Angel I. Blanco , K. S. Clifford Chao , Gokhan Ozyigit , Mustafa Adli , Wade L. Thorstad , Joseph R. Simpson , Gershon J. Spector , Bruce Haughey and Carlos A. Perez
杂志全名： International Journal of Radiation Oncology*Biology*Physics
年份，卷（期）: 起止页码： Volume 59, Issue 1, 1 May 2004, Pages 51-58
英文摘要：
Purpose: To assess the clinical features, prognostic factors, results, and complications of treatment of carcinomas of the paranasal sinus.
Methods and materials: The records of 106 patients (72 men and 34 women) with paranasal sinus carcinoma treated with curative intent at Washington University between January 1960 and August 1998 were analyzed. Patient age ranged from 29 to 91 years (median, 64 years). Most tumors originated in the maxillary (76%) or ethmoid (18%) sinus. Most tumors were locally advanced at presentation. All patients underwent radiotherapy (RT), combined with surgery in 65%; 2% received chemotherapy.
Results: Follow-up ranged from 1.7 months to 24 years (median 5 years). The 5-year local tumor control, locoregional tumor control, disease-free survival (DFS), and overall survival rate was 58%, 39%, 33%, and 27%, respectively. A statistically significant improvement in DFS was noted with the addition of surgical resection to RT (35% vs. 29%, p = 0.05). Nodal status at presentation emerged as a statistically significant predictor for locoregional tumor control and DFS in multivariate analysis. Distant metastases occurred in 29% of patients.
Conclusion: This review of a large, single-institution experience of paranasal sinus carcinoma patients who underwent RT showed that locoregional tumor progression and recurrence remain predominant patterns of failure despite aggressive local treatment with combined surgery and RT. DFS improved slightly with combined modality treatment. The overall survival rates remained suboptimal, suggesting a need for more accurate determination of tumor extent, as well as more effective locoregional and systemic therapies.
中文译文：
副鼻窦癌放射治疗长期疗效
目的：评价上颌窦癌的临床特点，预后因素，结局以及治疗的并发症。
材料与方法：分析自1960年1月至1998年8月间在华盛顿大学进行治疗的106例副鼻窦患者（其中男性72例，女性34例）。患者年龄29～91岁，中位年龄64岁。大部分肿瘤源于上颌窦（占76%）和筛窦（占18%）。多数肿瘤为局部晚期。所有的患者均进行了放射治疗，其中65%联合手术治疗，2%接受了化疗。
结果：随访时间为1.7个月到24年（中位时间为5年）。5年局部肿瘤控制率，局部区域肿瘤控制率，无病生存率和总生存率分别为58%，39%，33%和27%。放疗加手术治疗改善患者的无病生存率具有明显的统计学意义（放疗加手术治疗与单纯放疗的无病生存率分别为35%和29%，p=0.05）。淋巴结状态对于预测局部区域肿瘤控制率和无病生存率在多变量分析中具有显著的统计学意义。患者的远处转移率为29%。
结论：这项对在一个大型医疗机构进行放射治疗的副鼻窦癌患者的回顾性研究显示：尽管进行积极的放疗加手术的综合治疗，副鼻窦癌治疗失败的主要原因仍然是局部区域肿瘤进展和复发。综合治疗仅能轻微的提高患者的无病生存率。总生存率仍然较差，建议在进行更加有效的局部区域和全身性治疗的同时，需进一步更加明确肿瘤的侵犯范围。
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文题：Carcinoma of paranasal sinuses: long-term outcomes with radiotherapy
作者：Angel I. Blanco , K. S. Clifford Chao , Gokhan Ozyigit , Mustafa Adli , Wade L. Thorstad , Joseph R. Simpson , Gershon J. Spector , Bruce Haughey and Carlos A. Perez
杂志全名： International Journal of Radiation Oncology*Biology*Physics
年份，卷（期）: 起止页码： Volume 59, Issue 1, 1 May 2004, Pages 51-58
英文摘要：
Purpose: To assess the clinical features, prognostic factors, results, and complications of treatment of carcinomas of the paranasal sinus.
Methods and materials: The records of 106 patients (72 men and 34 women) with paranasal sinus carcinoma treated with curative intent at Washington University between January 1960 and August 1998 were analyzed. Patient age ranged from 29 to 91 years (median, 64 years). Most tumors originated in the maxillary (76%) or ethmoid (18%) sinus. Most tumors were locally advanced at presentation. All patients underwent radiotherapy (RT), combined with surgery in 65%; 2% received chemotherapy.
Results: Follow-up ranged from 1.7 months to 24 years (median 5 years). The 5-year local tumor control, locoregional tumor control, disease-free survival (DFS), and overall survival rate was 58%, 39%, 33%, and 27%, respectively. A statistically significant improvement in DFS was noted with the addition of surgical resection to RT (35% vs. 29%, p = 0.05). Nodal status at presentation emerged as a statistically significant predictor for locoregional tumor control and DFS in multivariate analysis. Distant metastases occurred in 29% of patients.
Conclusion: This review of a large, single-institution experience of paranasal sinus carcinoma patients who underwent RT showed that locoregional tumor progression and recurrence remain predominant patterns of failure despite aggressive local treatment with combined surgery and RT. DFS improved slightly with combined modality treatment. The overall survival rates remained suboptimal, suggesting a need for more accurate determination of tumor extent, as well as more effective locoregional and systemic therapies.
中文译文：
副鼻窦癌放射治疗长期疗效
目的：评价上颌窦癌的临床特点，预后因素，结局以及治疗的并发症。
材料与方法：分析自1960年1月至1998年8月间在华盛顿大学进行治疗的106例副鼻窦患者（其中男性72例，女性34例）。患者年龄29～91岁，中位年龄64岁。大部分肿瘤源于上颌窦（占76%）和筛窦（占18%）。多数肿瘤为局部晚期。所有的患者均进行了放射治疗，其中65%联合手术治疗，2%接受了化疗。
结果：随访时间为1.7个月到24年（中位时间为5年）。5年局部肿瘤控制率，局部区域肿瘤控制率，无病生存率和总生存率分别为58%，39%，33%和27%。放疗加手术治疗改善患者的无病生存率具有明显的统计学意义（放疗加手术治疗与单纯放疗的无病生存率分别为35%和29%，p=0.05）。淋巴结状态对于预测局部区域肿瘤控制率和无病生存率在多变量分析中具有显著的统计学意义。患者的远处转移率为29%。
结论：这项对在一个大型医疗机构进行放射治疗的副鼻窦癌患者的回顾性研究显示：尽管进行积极的放疗加手术的综合治疗，副鼻窦癌治疗失败的主要原因仍然是局部区域肿瘤进展和复发。综合治疗仅能轻微的提高患者的无病生存率。总生存率仍然较差，建议在进行更加有效的局部区域和全身性治疗的同时，需进一步更加明确肿瘤的侵犯范围。
版权声明：本译文文字内容版权归丁香园网站（ http://www.dxy.cn ）所有，未经本网站书面许可，请勿转载或摘编。
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