【专题讨论】本站站友向甘辉立教授提问专贴（肺栓塞相关问题）(活动结束，置顶继续学习)

热烈欢迎甘辉立教授做客丁香园！请站友们就肺栓塞相关问题向甘辉立教授请教！感谢甘辉立教授在百忙之中来丁香园为我们讲座答疑！

一、甘辉立教授简介：

甘辉立教授，医学博士，北京安贞医院心血管外科主任医师。中华医学会胸心血管外科分会会员、中华医师协会胸心血管外科分会会员。2004至2006年曾派赴美国克里夫兰医学中心（CCF）、费城儿童医院心脏中心、宾州大学医学院心脏中心、圣地亚哥医学中心Thornton医院、UCLA医学中心深造。2009年派赴美国亚特兰大Cryolife中心深造。
担任《Journal of Thoracic and Cardiovascular Surgery》、《Cardiovascular Therapeutics》、《Vasc Health Risk Manag.》等SCI收录杂志同行评议审稿人，担任《微循环学》杂志编委，《PRAGMATIC AND OBSERVATIONAL RESEARCH》杂志荣誉编委。2005年获得北京市科学技术奖二等奖：《先天性心脏病合并重度肺动脉高压的外科治疗策略》。发表心血管外科论文60余篇，其中MEDLINE收录18篇，SCI收录12篇，参编心血管外科专著6部。《Congenital Systemic-to-pulmonary Shunts with Severe Pulmonary Artery Hypertension: Comparison of Outcome of Surgical or Non-surgical Treatment adjusted by Propensity Score》一文在澳大利亚召开的第五届世界儿童心脏病学和心脏外科大会(the 5th World Congress of Paediatric Cardiology and Cardiac Surgery)大会宣读。作为主编、副主编及编者，编写全国高等学校规划教材及医学专著6部。
从事心血管外科二十五年。研究方向主要集中肺动脉高压，从事先天性心脏病合并重度肺动脉高压，急、慢性肺动脉栓塞，尤其是慢性栓塞性肺动脉高压、特发性肺动脉高压方面临床研究二十余年。在左向右分流型先天性心脏病合并重症肺动脉高压的研究方面，成功治疗一组重症肺动脉高压的先心病人，手术成功率高达95%，救治了一批传统方法不能治疗的病人。
在急性肺动脉栓塞、慢性栓塞性肺动脉高压方面，主要集中于手术治疗、非手术治疗肺栓塞的临床研究。在世界上首次提出了慢性栓塞性肺动脉高压的中央型、外周型分型方案（安贞医院分型方案），用于术前评估慢性栓塞性肺动脉高压的手术可能性、术中术后危险因子的预测。在国内最先开展重症急性肺动脉栓塞取栓治疗及慢性栓塞性肺动脉高压的手术治疗，取得了成功经验；并对100余例急、慢性肺动脉栓塞完成肺动脉血栓内膜剥脱术，为国内最大一组病例，取得良好疗效。

学历

1981.09-1986.07湖北医科大学(现武汉大学医学院)医疗系 本科，学士学位
1986.09-1989.07湖北医科大学(现武汉大学医学院)心胸外科 硕士，硕士学位
1995.09-1998.07首都医科大学心胸血管外科 博士，博士学位
2005.03-2006.03美国宾州大学医学院 、圣地亚哥医学中心 高级访问学者

工作经历

1989.07-1992.09 武汉大学附属武汉市三医院心胸外科 住院医师
1992.09-1994.09 武汉大学附属武汉市三医院心胸外科 主治医师、讲师
1994.09-1999.09 首都医科大学附属安贞医院心胸外科 主治医师、讲师
1999.09-2007.1 首都医科大学附属安贞医院心胸外科 副主任医师、副教授
2007.11月-目前 首都医科大学附属安贞医院心胸外科 主任医师、教授
2005.03-2006.03 美国宾州大学医学院、圣地亚哥医学中心 高级访问学者

主要学术任职

中华医学会胸心血管外科分会会员
中华医师协会胸心血管外科分会会员
《Journal of Thoracic and Cardiovascular Surgery》杂志同行评议审稿人
《Cardiovascular Therapeutics》杂志同行评议审稿人
《Vasc Health Risk Manag.》杂志同行评议审稿人
《生物医学与环境科学》杂志同行评议审稿人
《微循环学》杂志编委
《Pragmatic and Observational Research》荣誉编委
CHEST-1及CHEST-2 研究可手术性国际评估人

在研项目

2006.01-2010.12．国家十一、五科技支撑计划重大项目课题《提高肺动脉高压诊治水平的研究》（课题任务书编号：2006BAI01A07）子课题《国家肺动脉高压多中心、前瞻性登记注册研究》，作为独立研究者参加，正在进行中。
2011．01-2013．12：国家自然科学基金面上项目《肢体缺血后适应抑制肺泡巨噬细胞活化、预防治疗肺再灌注损伤机制的研究》，主要研究者（PI），正在进行中。
2009.01-2012.4 多国多中心随机对照研究CHEST-1 及CHEST-2研究 (新型降肺动脉压药物治疗不可手术治疗的慢性栓塞性肺动脉高压,作为LOCAL EXPERIENCED SURGEON参加,正在进行中。

学术奖励

2005年，北京市科学技术奖二等奖：先天性心脏病合并重度肺动脉高压的外科治疗策略。

心外科专长
1. 对于冠心病，采用双乳内动脉及桡动脉进行全动脉化，心脏不停跳，不输血进行微创搭桥手术。
2．瓣膜性心脏病成形手术和换瓣手术治疗，冠心病冠脉搭桥手术治疗。
3．对复杂先天性心脏病手术治疗，先心病合并肺动脉高压治疗有丰富经验
4．急性肺动脉栓塞、慢性栓塞性肺动脉高压的外科治疗。
5．采用胸部小切口方法微创手术，消融单发性房颤，对心房纤颤射频消融治疗有很深造诣。
6．主动脉瘤及主动脉夹层介入支架治疗及外科手术治疗。

发表论文

共发表论文70余篇，共中MEDLINE收录18篇，SCI收录12篇。

Publication

[1] Gan HL,Zhou QW,Zhang JQ, et al. The surgical treatment of acute pulmonary embolism. Chinese journal for thoracic and cardiovascular surgery, 1998, 14(3): 145-7.
[2] Gan HL, Zhou QW. Nitric oxide and pulmonary hypertension. Journal of Cardiovascular and Pulmonary diseases, 1997, 16(1): 78-9.
[3] Gan HL, Zhou QW. Experimental study of protective effects of ischemic preconditioning on myocardium during cardiopulmonary bypass. Chinese journal of Thoracic and Cardiovascular Surgery, 1999, 15(4): 245-7.
[4] Gan HL, Zhou QW. The progress in the minimally invasive cardiac surgery aided by robotics. Chinese Journal of Thoracic and Cardiovascular Surgery, 2001, 17(6): 377-8
[5] Gan HL, Zhang JQ, Chen H, Mu JS, Zhou QW, Wang SX, Zheng SH, Zhang XF, Liu S. Treatment of chronic thromboembolic pulmonary hypertension through pulmonary thromboendarterectomy and the effect of deep hypothermia circulation arrest thereon. National Medical Journal of China, 2007,87 (21):1482-5.
[6] Gan HL, Zhang JQ, Zhou QW, Chen H, Kong QY, Zheng SH, Mu JS . The short and long-term results of valve replacement in children. Chinese Journal of Pediatric Surgery,2007,28 (7):374-7.
[7] Gan HL, Zhou QW. The analysis of the long term effect of tricuspid replacement. Chinese journal of surgery,2007,45 (16):1151-2.
[8] Gan HL, Zhang JQ , LI JY, Mu JS, Li WB, Bo P, Kong QY, Cao XR, Mao B. Ross procedure for aortic valve disease in children. Chinese Journal of Pediatric Surgery, 2007,28 (8):397-400.
[9] Gan HL, Zhang JQ, Zhang ZG, Zhou QW, Luo Y, Mu JS, Wang SX, et al. The clinical analysis of 54 cases for the surgical treatment of pulmonary embolism. Chinese Journal of Surgery,2008,46 (1):48-51.
[10] Gan HL, Zhang JQ, Zhang ZG, Luo Y, Mu JS, Zhou QW, et al. Prognosis of patients with chronic thromboembolic pulmonary hypertension receiving conservative or operative treatments according to a new clinical classiftcation scheme Chinese Journal of Cardiology, 2008，36(1):11-15.
[11] Gan HL, Zhang JQ, Mu JS, et al.The Early and Middle-long Term Clinical Outcome of Surgical Treatment of Pulmonary Embolism. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2008,15 (1):1-6.
[12] Gan HL, Zhang JQ. Statins and pulmonary hypertension. Chinese Journal of Microcirculation,2008, 18 (1):53-6.
[13] Gan HL. Update on the research between pulmonary hypertension and PDE. Journal of Cardiovascular and Pulmonary diseases, 2009, 28(1): 64-6
[14] Gan HL, Zhang JQ, Wang SX, Zhou QW, Kong QY, Zheng SH, BO P, Huang GH, Chen W Repair of anterior leaflet mitral valve prolapse: the comparison between chordal replacement and chordal shortening. Chinese Journal of Surgery, 2008; 46(22):1727-9
[15] Gan HL, Zhang JQ, Wang SX, Zhou QW, Kong QY, Zheng SH, Bo P, Huang GH, Chen W. The Early and Middle-long-term Clinical Results of Tricuspid Valve Replacement. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2008; 15(4): 249-54.
[16] Gan HL, Zhang JQ, Ge YQ, Zhou QW, Kong QY, Zheng SH, Mu JS, Bo P. The Clinical Research of Tricuspid Valve Replacement in the Treatment of Ebstein's Anomaly. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2008; 15(5): 336-34.
[17] Gan HL, Zhang JQ, Luo Y, Wang SX, Li WB, Zhou QW. The diagnosis and surgical treatment of 11 cases of pediatric aortic origin of the right pulmonary artery. Chinese Journal of Pediatric Surgery 2009; 30(2):68-71.
[18] Gan HL, Zhang JQ, BO P, Zhou QQ, Wang SX Zheng SH. The anatomic pathological classification for intracardiac leiomyomatosis and the choice of its surgical strategy. Chinese Medical Journal, 2008; 88(47): 3362-3364.
[19] Gan HL, Zhang JQ, Luo Y, Wang SX, LI WB, ZHOU QW. Diagnosis and treatment of aortic origin of the right pulmonary artery: analysis of 14 cases. Chinese medical journal 2009; 89(11): 763-5.
[20] Gan HL, Zhang JQ, Chen BT, et al. The early and middle-long term clinical results of surgical treatment for ventricular septal rupture. Chinese Journal of Surgery, 2009(3); 47(6): 457-60.
[21] Gan Hl, Zhang JQ. Occupying the whole pulmonary artery: chronic thromboembolic pulmonary hypertension. Eur J Cardiothorac Surg 2009;35 (4):725.
[22] Gan HL, Zhang JQ.A special type of endovascular stent repair with complicated thoracic aneurysm and chronic type B dissection aligned in tandem: double perfusion in true and false distal aorta lumen. Chinese Medical Journal 2008; 121(15):1484-6.
[23] Gan HL, Zhang JQ. Diagnosis and surgical treatment of post-infarction left ventricular pseudoaneurysm. Chinese Medical Journal 2009; 122(2): 232 -5.
[24] Gan HL, Zhang JQ, Bo P, Wang SX, et al. Statins decrease adverse outcomes in coronary artery bypass for extensive coronary artery disease as well as left main coronary stenosis. Cardiovascular Therapeutics 2010; 28.2: 70-9.
[25] Gan HL, Zhang JQ, Zhou QW, Bo P. The Actuarial Survival Analysis of the Surgical and Non-surgical Therapy Regimen for Chronic Thromboembolic Pulmonary Hypertension. Journal of thrombosis and thrombolysis, 2010 ;29 (1):25-31.
[26] Gan HL, Zhang C, Zhang JQ. Closure of a Two-Hole Secundum Atrial Septal Defect through a Transthoracic Atrial Septal Defect Occlusion Device. World Journal of Pediatric Congenital Heart Surgery, 2010,1(1):140-2.
[27] Gan HL, Zhou QW. The protective effect of subischemic preconditioning on lung tissue during open heart surgery under cardiopulmonary bypass. Journal of Cardiovascular and Pulmonary Diseases, 2002, 21(3):172-174.
[28] Gan HL, Zhang JJQ, Liu S, et al. Clinical analysis of 62 cases of chronic thromboembolic pulmonary hypertension treated with pulmonary thromboendarterectomy without early and late deaths. Chinese Medical Journal, 2009,89 (19):1330-3.
[29] Gan HL, Zhang JQ, Zhou QW, Bo P. Congenital Systemic-to-pulmonary Shunts with Severe Pulmonary Artery Hypertension: Comparison of Outcome of Surgical or Non-surgical Treatment adjusted by Propensity Score. Oral presented at The 5th World Congress of Paediatric Cardiology and Cardiac Surgery (June, 2009, Australia).
[30] Gan HL, Zhang JQ, Zhou QW. The actuarial analysis to the surgical treatment and non-surgical treatment of congenital heart defects with severe pulmonary hypertension. Chinese Medical Journal, 2010, 90(17): 1162-11666.
[31] Gao YM, Liu S, Chen D, Gan HL. Causes of misdiagnosis of primary pulmonary artery sarcoma as pulmonary thromboembolism. Journal of Clinical Pulmonary Medicine, 2009, 14(5) 592-594.
[32] Gan HL, Zhang JQ, Liu S, Xiao Y, Zhu GF, Zhang XF, Gao YM, Zhou QW. The diagnosis and treatment of paradoxical embolism originated from pulmonary embolism. Journal of Cardiovascular and Pulmonary Diseases, 2008, 27(5): 257-60
[33] Gan HL, Zhang JQ, Zhang ZG, Luo Y, Zhou QW, Bo P. The unidirectional valve patch provides no benefits to early and long-term survival in patients with ventricular septal defect and severe pulmonary artery hypertension. J Thorac Cardiovasc Surg. 2010; 139(4):950-5.
[34] Gan HL, Zhang JQ, Bo P, Wang SX, Lu CS. Statins decrease adverse outcomes in coronary artery bypass for extensive coronary artery disease as well as left main coronary stenosis. Cardiovasc Ther. 2010 Apr; 28(2):70-9.
[35] Gao YM, Liu S, Gan HL. The clinical significance of plasma N-terminal pro-brain natriuretic peptide levels in patients with pulmonary thromboemboembolism. Journal of Clinical Pulmonary Medicine. 2009, 29(5):441-3.
[36] Gan HL, Zhang C, Zhang JQ. Closure of a Two-Hole Secundum Atrial Septal Defect Through a Transthoracic Atrial Septal Defect Occlusion Device. World Journal for Pediatric and Congenital Heart Surgery 2010; 1 (1): 140-2.
[37] Gan HL, Zhang JQ, Liu S, Gao YM, Zhang XF, Zhu GF. The comparative study between proximal and distal type of chronic thromboembolic pulmonary hypertension treated with pulmonary thromboendarterectomy. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2010; 17:273-8.
[38] Gan HL, Zhang JQ, Huang F, Gu CX, Kong QY, Cao XR, Bo P, Lu CS. Prognosis of Percutaneous Coronary Intervention and Coronary Artery Bypass Grafts for Ostial Right Coronary Lesions in Propensity-Matched Individuals. Cardiovasc Ther. 2010 Aug 16. [Epub ahead of print].
[39] Gan HL, Zhang H, Zhang JQ, et al. The clinical analysis of 81 cases of chronic thromboembolic pulmonary hypertension treated with pulmonary thromboendarterectomy. Chinese Journal of Geriatric Heart Brain and Vessel Diseases 2011; 13(1):45-49.

二、 书讯：
由首都医科大学附属北京安贞医院心外科甘辉立教授独家编著的《PULMONARY EMBOLISM AND PULMONARY THROMBOENDARTERECTOMY》一书即将由纽约NOVA出版公司出版，其ISBN 978-1-61122-289-0，有感兴趣者现在即可向NOVA出版公司网站订购，网址为：
https://www.novapublishers.com/catalog/product_info.php?cPath=23_132_156&products_id=18646
全书原价为145美金，网上订购价为130.5美金。该书为全英文著作，全书421页，附图50余帧，为目前全世界第一本有关慢性栓塞性肺动脉高压（CTEPH）的专著。
肺动脉栓塞和慢性栓塞性肺动脉高压是严重威胁健康的疾病，死亡率和病残率都很高。肺动脉取栓术和肺动脉血栓内膜剥脱术治疗肺动脉栓塞和慢性栓塞性肺动脉高压可以取得很好的近、远期限手术效果。本书呈现这一领域最新的研究成果，而且本书还讲述与肺动脉血栓内膜剥脱术相关的呼吸系统、肺循环、支气管循环相关的解剖及生理知识、凝血与纤溶的生理与病理、血栓形成、抗凝与溶栓、深静脉血栓形成、急性肺动脉栓塞、慢性栓塞性肺动脉高压的基础与临床研究最新进展。本书适用于肺循环病学专家、心胸外科医师、肺影相学及相关领域的研究人员和医学生。

Pulmonary Embolism and Pulmonary Thromboendarterectomy
Authors: Huili Gan (Beijing Anzhen Hospital, Beijing, China)
Book Description:
Pulmonary embolism and chronic thromboembolic pulmonary hypertension are health devastating diseases with considerable morbidity and mortality. Pulmonary thrombectomy and pulmonary thromboendarterectomy are the procedures designed to treat pulmonary embolism and chronic thromboembolic pulmonary hypertension with very good early and long term effects. This book presents the latest research in this growing field. As a subsidiary and supporting knowledge to the pulmonary thromboendarterectomy, this book also provides knowledge relevant to the anatomy and physiology of respiratory system; pulmonary circulation and bronchial circulation; the physiology and pathophysiology of coagulation and fibrinolysis; the recent progress in thrombosis, anticoagulant and thrombolysis, deep vein thrombosis, acute pulmonary embolism and chronic thromboembolic pulmonary hypertension. (Imprint: Nova Biomedical Press)

Table of Contents:
Foreword by the author

Chapter 1: The Anatomy and Physiology of the Respiratory System, Pulmonary Circulation, Bronchial Circulation, and Leg vein

Chapter 2: Coagulation and Fibrinolysis

Chapter 3: Thrombosis

Chapter 4: The Anticoagulant and Thrombolysis

Chapter 5: Deep Venous Thrombosis

Chapter 6: Acute Pulmonary Embolism

Chapter 7: Chronic Thromboembolic Pulmonary Hypertension

Chapter 8: Pulmonary Thrombectomy And Pulmonary Thromboendarterectomy

Chapter 9: The Management of Acute Pulmonary Hypertension

Series:
Cardiology Research and Clinical Developments
Binding: Hardcover
Pub. Date: 2011 1st quarter
Pages: 7 x 10 (NBC - C)
ISBN: 978-1-61122-289-0
Status: AP

Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available

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